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IntroductionCoverIntroductionProSureClinical StudiesSupportingPublicationsEPA -eicosapentaenoic acidThis compendium includes a summary of 29 publications based on21 clinical studies conducted with ProSure, a therapeutic nutritionalproduct scientifically formulated to address the nutritional needsof people with cancer-induced weight loss or who are at risk fordeveloping this complication. These 21 studies have been conductedin patients with a range of cancer types including: pancreatic, lung,head and neck, colorectal, esophageal, and solid tumors and leukemiain children. A supporting publications section is included in thiscompendium that includes summaries of clinical studies that supportthe use of fish oil supplements in patients with cancer. Other papersincluded in this section are an international consensus definition andclassification of cancer cachexia and a minireview paper of studiesthat evaluated the role of eicosapentaenoic acid on lean body mass incancer cachexia.People with cancer often experience weight loss along with a lossof quality of life—conditions that reach far beyond the battle againstmalignant cell growth. Unintended weight loss is sometimes the firstsign of cancer a patient notices, but weight loss is just one aspect ofa more complicated condition known as cancer cachexia. Cachexiamay also lead to anorexia, anemia, muscle loss, decreased strength,and physical and mental fatigue. Such impairments can in turn lead tomalnutrition, social isolation, and depression.Cancer cachexia has recently been defined by an internationalconsensus panel as a multifactorial syndrome defined by an ongoingloss of skeletal muscle mass (with or without loss of fat mass) thatcannot be fully reversed by conventional nutritional support andleads to progressive functional impairment. The pathophysiologyis characterised by a negative protein and energy balance drivenby a variable combination of reduced food intake and abnormalmetabolism. Cancer cachexia is caused by factors that are releasedby certain tumors and by the host’s inflammatory response to thepresence of the tumor. These factors depress appetite and impairthe body’s metabolism of dietary fat, protein, and carbohydrate.Such changes actually begin before weight loss is evident and canworsen as cancer progresses. Studies have shown that cancercachexia can be managed in part by specialized nutrition. ProSure isclinically proven to benefit people with cancer. If weight loss due tocancer cachexia is not effectively treated, poor outcomes can result.Such outcomes include decreased response to cancer treatments,increased frequency of complications and infections, and shortenedsurvival. In addition to survival, people with cancer are particularlyconcerned about restoring and maintaining quality of life.Clinical studies demonstrate that drinking ProSure daily as part of anoverall cancer care plan:• Promotes weight gain• Helps build or maintain lean body mass• Improves physical activity• Improves quality of life• Increases strength• Improves appetite and dietary intake• Attenuates the proinflammatory responseProSure is enriched with eicosapentaenoic acid (EPA), which helpsdecrease the harmful metabolic changes induced by tumor-relatedfactors. Calorically dense with a high amount of protein, ProSure helpsbuild lean body mass. ProSure’s unique combination of EPA withprotein- and energy-rich ingredients helps counter the physiologicalabnormalities that underlie weight loss due to cancer cachexia. Forcancer patients, ProSure is recommended as two 240-mL servingsper day along with regular food consumption. Studies have shownthat adding ProSure to the diet does not inhibit usual meal intake butactually improves appetite so that meal intake improves.
CoverIntroductionProSureClinical StudiesSupportingPublicationsThis is a navigatablebook shelf. Click onthe books to view eachProSure® publication.Head/Neck GI Other
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Page 15 and 16: A double blind randomized controlle
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Cover Introduction ProSure Clinical Studies ... - Abbott Nutrition

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