EPID 766: Analysis of Longitudinal Data from ... - NCSU Statistics

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CHAPTER 1 Epid 766, D. Zhang Example 3: Epileptic seizure counts from progabide trial In progabide trial, 59 epileptics were randomly assigned to receive anti-epileptic treatment (progabide) or placebo. The number of seizure counts was recorded in 4 consecutive 2-week intervals. Age and baseline seizure counts (for an 8 week period prior to treatment assignment) were also recorded. Study objectives: • Does the treatment work? • What is the treatment effect adjusting for available covariates? Features of this data set: 1. Outcome is count data, implying Poisson regression. 2. Baseline seizure counts were for 8 weeks, as opposed to 2 weeks for other seizure counts. 3. Randomization may be taken into account in data analysis. Graduate Summer Session in Epidemiology Slide 18
CHAPTER 1 Epid 766, D. Zhang Epileptic seizure counts from progabide trial Seizure counts 0 50 100 150 Seizure counts for progabide arm 0 1 2 3 4 Order of visit Seizure counts 0 50 100 150 Seizure counts for control arm 0 1 2 3 4 Order of visit Graduate Summer Session in Epidemiology Slide 19
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