EPID 766: Analysis of Longitudinal Data from ... - NCSU Statistics

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CHAPTER 1 Epid 766, D. Zhang • Summary from Stage II: 1. Comparison of E(b0) and E(b1) between males and females: �E( � b0) : 223.97(female), 217.6(male), p-value = 0.28 �E( � b1) : 1.75(female), 3.31(male), p-value = 0.002. 2. Comparison of var(b0) and var(b1) between males and females: S 2b0 S 2b1 : 1621(female), 1848(male), p-value = 0.5 : 11.3(female), 13.9(male), p-value = 0.3. However, the above tests do NOT compare var(b0) and var(b1) between males and females. We will use mixed model approach to address this problem. 3. Model for true baseline response b0: � b0 = α0 + α1sex + α2age + e0, �α0 = 138.2(15.0), �α1 = −9.75(5.5), �α2 = 2.06(0.35). Graduate Summer Session in Epidemiology Slide 44
CHAPTER 1 Epid 766, D. Zhang After adjusting for sex, one year increase in age corresponds to 2 unit increase in baseline cholesterol level. After adjusting for baseline age, on average males’ baseline cholesterol level is about 10 units less than females’. 4. Model for change rate of the true response b1: � b1 = β0 + β1sex + β2age + e1, �β0 = 6.14(1.35), � β1 = 1.74(0.5), � β2 = −0.11(0.03). After adjusting for sex, one year increase in age corresponds to 0.11 less in cholesterol level change rate. After adjusting for baseline age, males’ cholesterol level change rate is 1.74 greater than females’. Graduate Summer Session in Epidemiology Slide 45
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