Core facilities at EMBL â an overview - Molmedrex Project

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Regulation of ERα responsive genesHOCH3 OHE2HMTsHATs,HDACsMediatorTRANSCRIPTION:GX microarrays,qPCR GX analysis,miRNA profiling,SAGELOCATION ANALYSIS:ChIP-on-chip, ChIP-qPCRData analysisNuclearreceptorNucleosomesEPIGENETICS:“Bisulfite” sequencingDNMTsTarget genesBy courtesy of G. Reid& S. Kangaspeska
New-gen sequencing on SolexaState-of-the-matter:Hardware – 3 GAIIx with paired-end modulesSoftware, IT infrastructure – data processing pipeline inplace but continuously updated from the Illumina side- data storage management with IT ServicesPreparation of seq libraries – under reasonable control,almost all sample types tested, Covaris, HydroShearData analysis – in-house SW solutions, Genomatix GenomeAnalyzer & Mapper, DNAStar Ngen, collaboration withEBI
Page 1 and 2: Core facilities at EMBL -an overvie
Page 3: Research & Core Facilities at EMBLP
Page 6 and 7: Core Facilities at EMBL• Advanced
Page 8 and 9: Unlocking the genomeCelniker et al.
Page 10 and 11: GeneCore ServicesLiquid handling ro
Page 12 and 13: GeneCore ServicesComplete support &
Page 16 and 17: EMBL Solexas• ~180 million reads
Page 18 and 19: Cluster generationPrepare DNAfragme
Page 20 and 21: Applications at EMBL• Whole-genom
Page 22 and 23: Challenges• ChIP-Seq and RNA-Seq
Page 25 and 26: AcknowledgementRichard CarmoucheJü

Core facilities at EMBL â an overview - Molmedrex Project

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Core facilities at EMBL â an overview - Molmedrex Project