Molecular Biology Databases - CNB - Protein Design Group

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PROTEIN DATABASESUniProtKB/TrEMBL• Translations of all coding sequences present in the EMBL/GenBank/DDBJ• Automatic annotation and classification• Proteins that get manually annotated go to UniProtKB/Swiss-Prot• 5,395,414 entries in UniProtKB/TrEMBL (Feb. 2008)
STRUCTURE DATABASESProtein Data Bank• RCSB PDB (USA), MSD-EBI (Europe), PDBj (Japan) and BMRB (USA)• To maintain a single Protein Data Bank Archive of macromolecular structuraldata that is freely and publicly available• Protein and nucleic acid structures• X-ray crystallography, NMR and electron microscopy• More than 49000 structures (Feb 2008)
Page 1 and 2: MOLECULAR BIOLOGYDATABASESJuan Carl
Page 3 and 4: Ouellette, 2000
Page 5 and 6: GROWING NUMBER OF DATABASESThe numb
Page 7 and 8: HOW TO ACCESS DATABASESDatabases ar
Page 9 and 10: CONTENT OF PRIMARY DATABASESExperim
Page 11 and 12: CLASSIFICATION OF MOLECULARBIOLOGY
Page 13 and 14: DATABASE SEARCHES:QUERY TYPESTEXT Q
Page 15 and 16: DATABASE SEARCHES:QUERY TYPESQUERIE
Page 17 and 18: NUCLEOTIDE DATABASESGenBank• Main
Page 19 and 20: GENOME DATABASESEnsemblEnsembl, EBI
Page 21 and 22: GENOME DATABASESEntrez Genome• In
Page 23 and 24: GENE-CENTERED DATABASESComplete inf
Page 25 and 26: PROTEIN DATABASESNon-redundant data
Page 27: PROTEIN DATABASESUniProtKB/Swiss-Pr
Page 31 and 32: PROTEIN DOMAINS DATABASESProtein do
Page 33 and 34: GENE EXPRESSION DATABASESGene expre
Page 35 and 36: PATHWAY DATABASESDisplay metabolic
Page 37 and 38: ONTOLOGIES IN MOLECULAR BIOLOGYCont
Page 39 and 40: GENE ONTOLOGYDeveloped and maintain
Page 41 and 42: GenBank and EMBL● GenBank and the
Page 43 and 44: • Entrez is the indexing and data
Page 45 and 46: MAIN DATABASESACCESIBLE WITH ENTREZ
Page 47: FASTA format> essentialGIAccession.
Page 50 and 51: GBFF: FEATURESFEATURESLocation/Qual
Page 52 and 53: EMBL AND SwissProt FORMATThe field
Page 54 and 55: EMBL AND SwissProt FORMATFT source
Page 58 and 59: • Sequence Retrieval System is a
Page 60: ACKNOWLEDGMENTSThis presentation co

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