Special Issue CommentaryOpiate Addiction and Prescription Drug <strong>Abuse</strong>:A Pragmatic Approachby Khalid M. Hasan, MD andOmar K. Hasan, MDDur<strong>in</strong>g this second decade ofthe 21st century, the United<strong>State</strong>s is <strong>in</strong> the midst of amajor public health problem. At nearepidemic proportions, the abuse ofprescription drugs and especiallyopiates significantly contributesto escalat<strong>in</strong>g care costs, <strong>in</strong>creas<strong>in</strong>gpatient hospitalizations, and grow<strong>in</strong>gnumbers of untimely deaths.Although tobacco, alcohol,and marijuana traditionally haverepresented the drugs of choicefor adolescents, recreational use ofpharmaceuticals has the potential tobecome as prevalent. This is due toprescription medications’ relativelow cost, ready availability, andaccepted medical usage. In addition,the problem is exasperated by asmall percentage of unscrupulousproviders who for f<strong>in</strong>ancial ga<strong>in</strong>play a major role <strong>in</strong> this epidemic.Some may question the usage ofthe term epidemic; however, statisticsbear the appropriateness of thisappellation. Approximately 14%of American adults are estimatedto be us<strong>in</strong>g pa<strong>in</strong> medications fornonmedical purposes, and therecreational usage of opioids hassteadily risen dur<strong>in</strong>g the past decade.From 2002 to 2006, the percentage ofyoung adults aged 18 to 25 abus<strong>in</strong>gprescription opioids <strong>in</strong>creasedfrom 4.1% to 4.6%. These figuressuggest that approximately 1.5million young adults are regularlyabus<strong>in</strong>g these medications.Additionally, opioid-relatedemergency room visits <strong>in</strong>creased126% from 2004 to 2008. Treatmentadmissions for non-hero<strong>in</strong> opioidabuse and dependence are alsoon the rise. From 1996 to 2006, thenumbers of these treatments nearlyquadrupled nationally from 16,605to 74,750. In <strong>West</strong> Virg<strong>in</strong>ia, thistrend especially has been severe.Dur<strong>in</strong>g the same ten-year period,non-hero<strong>in</strong> opioid treatments soared<strong>in</strong> the Mounta<strong>in</strong> <strong>State</strong> from twotreatments per every 100 thousandto 78 <strong>in</strong> every 100 thousand.Currently, <strong>West</strong> Virg<strong>in</strong>ia has thethird highest non-hero<strong>in</strong> opioidtreatment rate <strong>in</strong> the nation.While we believe that the majorityof physicians are treat<strong>in</strong>g patientpa<strong>in</strong> appropriately, a number<strong>in</strong>discrim<strong>in</strong>ately prescribe opiates.This is done without a propertreatment plan of when and howto use the medications, withoutassess<strong>in</strong>g the illness for the need ofsuch medications, and a lack of useof standardized pa<strong>in</strong> assessment<strong>in</strong>struments. Some physiciansrout<strong>in</strong>ely neglect alternativesto narcotics for treatment suchas psychosocial and behavioraltechniques as well as non-addictiveadjunctive medic<strong>in</strong>es to reducedependencies on opioids. The resulthas created a culture of iatrogenicdrug addiction, and the offend<strong>in</strong>gproviders are ascribed as be<strong>in</strong>g“legalized drug pushers.” It is our<strong>in</strong>tention to propose pragmaticchanges to physician practices toaddress this ever grow<strong>in</strong>g problem.Pa<strong>in</strong> Management: Prescriptionof narcotics for non-cancer pa<strong>in</strong>should be a treatment that is timelimitedand of a last resort. It shouldonly be used when non-narcoticand psychosocial <strong>in</strong>terventionshave failed. Even when legitimatelyused, the prescriptions should<strong>in</strong>clude a dosage, quantity, andtreatment duration that is adequateto treat the pa<strong>in</strong>. Monitor<strong>in</strong>g theusage of these medications reducesthe risk of patient abuse anddependence, and it decreases thelikelihood of diversion through thedrug’s sale or theft. S<strong>in</strong>ce divertedprescription pa<strong>in</strong> medications arethe lead<strong>in</strong>g source of opioid accessfor adolescents, the importance oflimit<strong>in</strong>g quantities of prescribednarcotics cannot be overstated.Opioid Treatment Dependence:Although methadone and levaacetylmethadol(LAAM) havebeen used as agonist replacementtreatments for opioid dependence,the <strong>Substance</strong> <strong>Abuse</strong> and MentalHealth Services Adm<strong>in</strong>istration arenow recommend<strong>in</strong>g buprenorph<strong>in</strong>e(Subutex ® ) and Suboxone ® , acomb<strong>in</strong>ation of buprenorph<strong>in</strong>eand naloxone, as office-basedtreatment alternatives for opioidaddictions. Physicians can belicensed to prescribe buprenorph<strong>in</strong>ewith m<strong>in</strong>imal tra<strong>in</strong><strong>in</strong>g and areonly required to be able to referpatients for adjunctive psychosocialtreatments. Unfortunately,buprenorph<strong>in</strong>e has developed a streetvalue. The duration of treatmentdosage of Suboxone ® has beendebated, but the medication has beensuccessful <strong>in</strong> the treatment of opioidaddicts. We believe, however, thatunless these medications are properlycontrolled, they will meet the samefate and notoriety of methadone.Motivation: Another factorthat plays an important role <strong>in</strong>the prognosis and treatment ofdrug addiction is motivation.Detoxification is not a cure. Whenutilized without adequate supportmeasures and proper follow-up,detoxification has proven to be<strong>in</strong>effective. While cont<strong>in</strong>uallyproblematic, assess<strong>in</strong>g an<strong>in</strong>dividual’s motivation is subjective.Although psychological tools exist,84 <strong>West</strong> Virg<strong>in</strong>ia <strong>Medical</strong> Journal
consequences or losses associatedwith drug use and abuse is a moreaccurate predictor of a patient’smotivation. These consequencesmay <strong>in</strong>clude be<strong>in</strong>g ostracizedsocially and religiously and may be<strong>in</strong>dicated by the losses of <strong>in</strong>come,jobs, professional licensures, and<strong>in</strong>timate relationships. As societybecomes more tolerant to theseissues, drug addiction and abusebecomes more pronounced. Oftenthe patient’s family and friendsignore or enable the addiction.Recommended TreatmentGuidel<strong>in</strong>es: While generalguidel<strong>in</strong>es for drug abusetreatment should be observed,we recommend the follow<strong>in</strong>g:a. Restrict<strong>in</strong>g the patient touse one pharmacy of his or herchoice throughout the treatment.b. Requir<strong>in</strong>g the patient to attendregular Narcotics Anonymous,Alcoholic Anonymous, orother treatment support groupmeet<strong>in</strong>gs. The patient shouldattend at least three sessionsper week dur<strong>in</strong>g the first threeto four months of treatment.These meet<strong>in</strong>gs can be graduallylessened after this time period.c. Obligat<strong>in</strong>g the patient to pay copayments<strong>in</strong> advance. Third partiescan assist by keep<strong>in</strong>g co-pays as lowas possible ($10 to $20 per session). Inaddition, we recommended requir<strong>in</strong>gMedicaid patients to pay a nom<strong>in</strong>alfee of $5 to $10 to demonstrateresponsibility towards the treatmentprocess. If patients fail to attenddesignated treatment and/orcounsel<strong>in</strong>g sessions, prescriptionsshould be withheld until such timeas the patient returns to compliance.d. Report<strong>in</strong>g excessive chargesby physicians and counselors tothe appropriate state agencies.e. Us<strong>in</strong>g standardized tests,such as pa<strong>in</strong> assessment tools, asabsolutely necessary. Document<strong>in</strong>gthe use of adjunctive treatmentmodalities rema<strong>in</strong>s important.f. Adm<strong>in</strong>ister<strong>in</strong>g a goal-directedtherapy with gradual taper<strong>in</strong>gof medication as the patientprogresses through treatment.g. Construct<strong>in</strong>g a patientagreement that <strong>in</strong>cludes randompill counts and monitored drugscreen<strong>in</strong>g that is strictly adheredto by the physician or therapist.h. Monitor<strong>in</strong>g and document<strong>in</strong>gthe patient’s wean<strong>in</strong>g process ofthe medication. This is especiallycritical when dosages havebeen <strong>in</strong>creased or have been ata high level for long periods.i. Requir<strong>in</strong>g physicians to completeperiodic tra<strong>in</strong><strong>in</strong>g and cont<strong>in</strong>u<strong>in</strong>geducation when dispens<strong>in</strong>g narcoticson a long-term basis. Licensurerenewal may be tied to the successfulcompletion of this tra<strong>in</strong><strong>in</strong>g.j. Collaborat<strong>in</strong>g betweenphysicians and addiction specialists iscritical.k. Limit<strong>in</strong>g the Suboxone ®treatment, <strong>in</strong> most cases, to not exceed16 mg per day.l. Document<strong>in</strong>g objective factors<strong>in</strong> detoxification <strong>in</strong>clud<strong>in</strong>g bloodpressure, pulse, respiration, diarrhea,rh<strong>in</strong>orrhea, and lacrimation.These should be comb<strong>in</strong>edwith subjective symptoms to<strong>in</strong>dividualized treatment.While the above mentionedtreatment recommendationsrepresent a practical approachemployed by physicians, theseare only part of the equation. Webelieve that these steps alone are<strong>in</strong>sufficient and additional actionat the public policy level is needed.These <strong>in</strong>clude the follow<strong>in</strong>g:First, the DEA’s regulationsfor Schedule II drugs with a highlikelihood for abuse need to beseriously evaluated. Such drugdispens<strong>in</strong>g should be restrictedand time-limited. Medicaid <strong>in</strong> <strong>West</strong>Virg<strong>in</strong>ia presently limits this to onemonth’s duration. In addition, tripleprescription copies are warranted.One copy would be kept on filewith the prescrib<strong>in</strong>g physician, onewith the dispens<strong>in</strong>g pharmacist,and one submitted to the DrugEnforcement Agency <strong>in</strong> order toreview and verify that the drugsare be<strong>in</strong>g dispensed properly.Second, the Board of Medic<strong>in</strong>eshould conduct periodic audits ofpatients’ charts and other physicianrecords for compliance with goodcl<strong>in</strong>ical practice guidel<strong>in</strong>es. This isespecially critical <strong>in</strong> regard to caseswhere physicians are prescrib<strong>in</strong>glarge numbers of narcotics.Third, an <strong>in</strong>creased level of publiceducation regard<strong>in</strong>g opiates andtheir <strong>in</strong>herent dangers needs tobe promoted via the media at thenational and local levels. Patientsmust be educated on the properdisposal of leftover portions of opioidprescriptions. This will contribute toa decrease <strong>in</strong> the number of divertedpa<strong>in</strong> medications sold on the street.Fourth, there should be greaterenforcement of providers accept<strong>in</strong>gprivate or government <strong>in</strong>surance(Medicaid and Medicare). Physiciansengaged <strong>in</strong> abusive charges <strong>in</strong>exchange for prescrib<strong>in</strong>g narcoticsneed to be reported to the Board ofMedic<strong>in</strong>e. Conversely, patients guiltyof doctor or pharmacy shopp<strong>in</strong>gshould be <strong>in</strong>vestigated by the properauthorities and the appropriatecharges be filed aga<strong>in</strong>st the patient.F<strong>in</strong>ally, controlled prospectivestudies need to be conducted todeterm<strong>in</strong>e treatment effectiveness ofSuboxone ® across multiple social andeconomic doma<strong>in</strong>s. Post treatmentfollow up needs to be conductedby <strong>in</strong>terviews and random drugtest<strong>in</strong>g for an additional year.Success would be determ<strong>in</strong>ed uponthe patient’s ability to resume,ma<strong>in</strong>ta<strong>in</strong>, and fulfill social andpersonal role obligations. Resultswould be triangulated through thecomparison with other studies.While prescription drug abuseexists <strong>in</strong> epidemic proportions, ithas the potential to spiral out ofcontrol to conditions not yet seen <strong>in</strong>modern society. The implementationof more str<strong>in</strong>gent guidel<strong>in</strong>esand broad-reach<strong>in</strong>g educationalprograms are imperative to stopthis cont<strong>in</strong>ually develop<strong>in</strong>g trend.SUBSTANCE ABUSE IN <strong>WV</strong> | Vol. 106 85