List <strong>of</strong> orig<strong>in</strong>al publicationsLIST OF ORIGINAL PUBLICATIONSThe thesis is based on the follow<strong>in</strong>g orig<strong>in</strong>al publications, which are referred to <strong>in</strong> the textby the Roman numerals I-V.I. Measurement <strong>of</strong> ascorbic acid (<strong>vitam<strong>in</strong></strong> C) <strong>in</strong>duced hydroxyl radicalgeneration <strong>in</strong> household dr<strong>in</strong>k<strong>in</strong>g <strong>water</strong>.Asplund, K.U.M., Jansson, P.J., L<strong>in</strong>dqvist, C. and Nordström, T.Free Rad Res. (2002) 36(12), 1271-1276.II.Vitam<strong>in</strong> C (ascorbic acid) <strong>in</strong>duced hydroxyl radical formation <strong>in</strong> coppercontam<strong>in</strong>atedhousehold dr<strong>in</strong>k<strong>in</strong>g <strong>water</strong>: Role <strong>of</strong> bicarbonateconcentration.Jansson, P.J., Asplund, K.U.M., Mäkelä, J.C., L<strong>in</strong>dqvist, C. and Nordström, T.Free Rad Res. (2003) 37(8), 901-905.III.Oxidative decomposition <strong>of</strong> <strong>vitam<strong>in</strong></strong> C <strong>in</strong> dr<strong>in</strong>k<strong>in</strong>g <strong>water</strong>.Jansson P.J., Jung H.R., L<strong>in</strong>dqvist C. and Nordström T.Free Rad Res. (2004) 38(8), 855-860.IV.Effects <strong>of</strong> iron on <strong>vitam<strong>in</strong></strong> C/copper-<strong>in</strong>duced hydroxyl radical generation<strong>in</strong> bicarbonate-rich <strong>water</strong>.Jansson P.J., Castillo U.D., L<strong>in</strong>dqvist C. and Nordström T.Free Rad Res. (2005) 39(5), 565-570.V. Iron prevents ascorbic acid (<strong>vitam<strong>in</strong></strong> C) <strong>in</strong>duced hydrogen peroxideaccumulation <strong>in</strong> copper-contam<strong>in</strong>ated dr<strong>in</strong>k<strong>in</strong>g <strong>water</strong>.Jansson P.J., L<strong>in</strong>dqvist C. and Nordström T.Free Rad Res. (2005) 39(11), 1233-1239.The orig<strong>in</strong>al publications have been repr<strong>in</strong>ted with the k<strong>in</strong>d permission <strong>of</strong> the copyrightholder Taylor & Francis, http://www.tandf.co.uk/journals.1
Contribution <strong>of</strong> the authorCONTRIBUTION OF THE AUTHORThe experimental work <strong>in</strong> the thesis was planned and conducted by the author togetherwith docent Tommy Nordström, with the follow<strong>in</strong>g aid from the co-authors.Klara U. M. Asplund performed most <strong>of</strong> the experiments <strong>in</strong> paper I.In paper II, Johanna C. Mäkelä assisted with the bicarbonate experiments.In paper III, Hye R. Jung measured dehydroascorbic acid formation <strong>in</strong> <strong>vitam<strong>in</strong></strong> Csupplemented dr<strong>in</strong>k<strong>in</strong>g <strong>water</strong>s with o-phenylenediam<strong>in</strong>e.In paper IV, Urko del Castillo helped with hydroxyl radical detection <strong>in</strong> <strong>vitam<strong>in</strong></strong>supplemented dr<strong>in</strong>k<strong>in</strong>g <strong>water</strong> samples.2
- Page 1 and 2: Pro-oxidant activity of vitamin C i
- Page 3 and 4: Supervised byDocent Tommy Nordströ
- Page 5 and 6: ContentsCONTENTSLIST OF ORIGINAL PU
- Page 10 and 11: AcknowledgementsACKNOWLEDGEMENTSThi
- Page 12 and 13: AbbreviationsABBREVIATIONSAsc …
- Page 14 and 15: Review of the literatureREVIEW OF T
- Page 16 and 17: Review of the literatureSince vitam
- Page 18 and 19: Review of the literaturestill added
- Page 20 and 21: Review of the literatureantioxidant
- Page 22 and 23: Review of the literatureThe α-toco
- Page 24 and 25: Review of the literatureCopper, wil
- Page 26 and 27: Review of the literatureOH • + H
- Page 28 and 29: Review of the literatureFormation o
- Page 30 and 31: Review of the literature3.2. The ro
- Page 32 and 33: Review of the literaturecopper conc
- Page 34 and 35: Experimental proceduresEXPERIMENTAL
- Page 36 and 37: Experimental procedures2.2. Measure
- Page 38 and 39: Experimental procedurestetrahydrate
- Page 40 and 41: ResultsRESULTS1. Vitamin C induces
- Page 42 and 43: Results3. Oxidative decomposition o
- Page 44 and 45: Resultsdifferent water samples vari
- Page 46 and 47: DiscussionDISCUSSIONNowadays, ascor
- Page 48 and 49: DiscussionCu 2+ + Asc → Cu + + As
- Page 50 and 51: Discussion3. Iron inhibits vitamin
- Page 52 and 53: Discussionperoxide might have an im
- Page 54 and 55: ConclusionsCONCLUSIONSThe main focu
- Page 56 and 57: ReferencesREFERENCES1. Arrigoni O,
- Page 58 and 59:
References34. Padayatty SJ, Katz A,
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References66. Sies H, Stahl W, Sund
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References95. Halliwell B. Role of
- Page 64 and 65:
References127. Park S, Han SS, Park
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References157. Critchley MM, Cromar
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References185. Liao CH, Kang SF, Wu
- Page 70 and 71:
References214. Orr CW. Studies on a
- Page 72:
References243. Miller C, Kennington
- Page 88 and 89:
Free Radical Research, Volume 38 Nu
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VITAMIN C OXIDATION IN DRINKING WAT
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VITAMIN C OXIDATION IN DRINKING WAT
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Free Radical Research, May 2005; 39
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Iron inhibits Vitamin C/copper-indu
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Iron inhibits Vitamin C/copper-indu
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Free Radical Research, November 200
- Page 102 and 103:
Hydrogen peroxide formation in drin
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Hydrogen peroxide formation in drin
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Hydrogen peroxide formation in drin
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