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TECHNICAL REPORTSystematic review and evidence-based guidance on perioperative antibiotic prophylaxisTable 1.4. Search of MEDLINE via PubMed for Objective 5Search Query#1 ((cohort*[TiAb] AND study*[TiAb] OR (observational study*[TiAb]) OR controlled before-and-afterstudy*[TiAb] OR CBAs[TiAb] OR interrupted time series[TiAb] OR ITS [TiAb])) AND (antibiotic* [TiAb] ORantimicrobial*[TiAb] OR antiinf*[TiAb]) AND (prophyla*[TiAb] OR preventive*[TiAb] OR prevention*[TiAb] ORpreventing [TiAb] OR premedication [TiAb]) AND (wound infection*[TiAb] OR surgical site infection*[TiAb].Itemsfound#2 ((multidrug-resistant bacteria) OR (Clostridium difficile-associated diarrhoea) OR clostridium difficile)) 14661#3 #1 AND #2 452531Table 1.5. Search of MEDLINE via PubMed for Objective 5Search Query#1 ((cohort*[TiAb] AND study*[TiAb] OR (observational study*[TiAb]) OR controlled before-and-afterstudy*[TiAb] OR CBAs[TiAb] OR interrupted time series[TiAb] OR ITS [TiAb])) AND (antibiotic* [TiAb] ORantimicrobial*[TiAb] OR antiinf*[TiAb]) AND (prophyla*[TiAb] OR preventive*[TiAb] OR prevention*[TiAb] ORpreventing [TiAb] OR premedication [TiAb]) AND (wound infection*[TiAb] OR surgical site infection*[TiAb].Itemsfound#2 ((multidrug-resistant bacteria) OR (Clostridium difficile-associated diarrhoea) OR clostridium difficile)) 14661#3 #1 AND #2 452531Table 1.6. Search of MEDLINE/Embase via OVID for Objective 5Search QueryItemsfound#1 surgical wound infection.mp. [mp=ti, ab, ot, nm, hw, ps, rs, ui, sh, tn, dm, mf, dv, kw] 26642#2 perioperative antibiotic prophylaxis.mp. [mp=ti, ab, ot, nm, hw, ps, rs, ui, sh, tn, dm, mf, dv, kw] 669#3 clostridium difficile.mp. [mp=ti, ab, ot, nm, hw, ps, rs, ui, sh, tn, dm, mf, dv, kw] 17275#4 clostridium difficile diarrhea.mp. [mp=ti, ab, ot, nm, hw, ps, rs, ui, sh, tn, dm, mf, dv, kw] 211#5 multi drug resistant bacteria.mp. [mp=ti, ab, ot, nm, hw, ps, rs, ui, sh, tn, dm, mf, dv, kw] 214#6 multi drug resistance.mp. [mp=ti, ab, ot, nm, hw, ps, rs, ui, sh, tn, dm, mf, dv, kw] 3099#7 3 or 4 or 5 or 6 20573#8 1 and 2 159#9 8 and 7 1#10 antibiotic prophylaxis.mp. [mp=ti, ab, ot, nm, hw, ps, rs, ui, sh, tn, dm, mf, dv, kw] 31562#11 1 and 10 2709#12 11 and 7 15Fourteen hits after removing duplicates from #12.45
Systematic review and evidence-based guidance on perioperative antibiotic prophylaxisTECHNICAL REPORTAnnex 2. Excluded studiesTable 2.1. Excluded studiesStudyAlkalin et al. 2000Allan et al. 2000Aziz et al. 2010Berenguer 2010Braxton et al. 2010Bucher et al. 2011Burke et al. 2010Campell et al. 2008Castello et al. 2006Chaberny et al. 2011Charrier et al. 2009Davis 2008 et al.Delgrado-Rodriguez 2001Diana et al. 2011Dull et al. 2008El-Badawi et al. 2009Enzler et al. 2011Finkelstein et al. 2005Goliembski et al. 2004Gorecki et al. 1999 et al.Gorevitch et al. 2008Gradl et al. 2011Graf et al. 2009Higuchi et al. 2010Hohmann et al. 2011Hübner et al. 2011Humphrey et al. 2009Hyman et al. 2010Jäger et al. 2006Karamboudis et al. 2010Kim et al. 2010Lau et al. 2010Lichtenberg et al. 2003Malangoni 2011McHugh et al. 2010Meyer et al. 2010Misteli et al. 2011Munoz-Platon et al. 1995O’Reilly et al.Pan et al. 2009Poubothu et al. 2009Rauk et al. 2010Rosenberger 2011Santini et al. 2009Schneeberger et al. 2002Schweon 2006Shah et al. 2010Suljagic et al. 2010Vries 2010Wacha et al.Reason for exclusionNon-systematic reviewNon-systematic reviewUnclear role of PAP in the prevention of SSIs since additional measures for their prevention were also reportedRetrospective review without controlQuestionnaire/surveillance without a controlNon-systematic reviewQuestionnaire/surveillance without a controlQuestionnaire/surveillance without a controlNo appropriate control providedNon-systematic reviewUnclear role of PAP in the prevention of SSIs since additional measures for their prevention were also reportedSevere methodological limitationsBefore–after study in a single Spanish hospital in 1989 patients; intervention consisted of reduction of preoperativestay; unnecessary chemoprophylaxis; reinforcement of aseptic management of surgical wound; appropriatemanagement of catheters without any information about the impact of PAP on SSIs as primary outcome. Nodefinition of unnecessary PAP.Questionnaire/surveillance without a controlSevere methodological limitationsNo full text available/no access to full textNon-systematic reviewUnclear role of PAP in the prevention of SSIs since additional measures for their prevention were also reportedNon-systematic reviewRetrospective analysis of appropriate PAP and antibiotic therapy and occurrence of CDAD; results are presented astotal use of antibiotics, irrespective of prophylaxis or therapy; no sufficient statistical analysis performed.Non-systematic reviewNon-systematic reviewUnclear role of PAP in the prevention of SSIs since additional measures for their prevention were also reportedProspective observational study surveying SSI after single PAP dose without a controlConference abstract; limited information; no full text publishedQuestionnaire/surveillance without a controlNon-systematic reviewConference abstract; limited information; no full text publishedNon-systematic reviewQuestionnaire/surveillance without a controlConflicting data in the abstract between text and tableUnclear role of PAP in the prevention of SSIs since additional measures for their prevention were also reportedConference abstract; limited information; no full text published.Non-systematic reviewNo appropriate control providedUnclear role of PAP in the prevention of SSIs since additional measures for their prevention were also reportedAim of study was evaluation of the microbiology of SSI; no controlsNo full text available/no access to full textSevere methodological limitationsQuestionnaire/surveillance without a controlNo appropriate control providedNo PAPNon-systematic reviewConference abstract; limited information; no full text publishedQuestionnaire/surveillance without a controlJournal article summarising reasons for SSI and prevention strategies (no original study, no systematic review)Questionnaire/surveillance without a controlSurveillance of SSI; no analysis of PAPConference abstract, no full text published yetNon-systematic review46
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