Professional Panel Screen by LC/MS/MS

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Collision Cell• 180 degree path– 40 degree pre-guide evacuation section– 100 degree collision cell (186 mm path)– 40 degree post-guide evacuation section• Curved for low noise and high sensitivity– Removes neutrals from the CID process– Positions the detector in off-axis from the source• Long path for wide CID energy range– Efficient dissociation of stable ions• Square geometry with flat surfaces– Larger cross sectional area for ion transmission• Collision cell without lenses– Decreased ion losses
Collision Cell: Curved DesignIonSourceNeutral Noise Positions the ion detector off-axis from the ionsource Removes photons, metastables, & high energycharged droplets from ion detectorDetectorIons
Page 1 and 2: Professional Panel Screen byLC/MS/M
Page 3 and 4: 1200L LC/MS & LC/MS/MSProStar Binar
Page 5 and 6: MRM Scanning of m/z Parent >Daughte
Page 7 and 8: Specimen Preparation for LC/MS/MS R
Page 9 and 10: LC/MS/MS for Screening?Advantages:1
Page 11 and 12: Tramadol with 246.0 m/z qualifier24
Page 13 and 14: Other Advantages of LC/MS/MS• Rap
Page 15: Ion Guides (Q1 and Q3)Pre-ion guide
Page 19 and 20: 1200L LC/MSElectrospray Ionization
Page 21 and 22: Off-axis Spray NeedleOff-axis orien
Page 23 and 24: Adjustable NebulizationLiquidNebuli
Page 25 and 26: Fully Adjustable SprayNeedleX-Adjus
Page 27 and 28: Desolvation andDeclusteringGasHeate
Page 29 and 30: Wide Bore, Metal CapillaryGasHeater
Page 31 and 32: ELECTROSPRAY IONIZATION (ESI)Mandat
Page 33 and 34: For ESI need low ionic strengths of
Page 35 and 36: Chromatogram Plots
Page 37 and 38: - 25 % Control
Page 39 and 40: Butorphanol (25 ng/mL cutoff)
Page 41 and 42: LOQ Control
Page 43 and 44: Typical Negative Screen
Page 45 and 46: Butorphanol +/- 25% ControlsLCMSMS
Page 47 and 48: 450400350300250200150100Meperidine
Page 49 and 50: 450400350300250200150100Meperidine
Page 51 and 52: Pentazocine +/- 25% ControlsLCMSMS
Page 53 and 54: 450400350300250200150100Tramadol +/
Page 55 and 56: Composite Precision: Professional P

Professional Panel Screen by LC/MS/MS

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