Nukleinsavak - Szerves Kémiai Tanszék

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A nukleinsavak kutatásának története1869. Meischer isolated nucleic acids, which he called nuclein.1880. Fischer identified pyrimidines and purines.1884. Hertwig suggested the role of nuclein in heredity.1910. Kossel was awarded the Noble prize for demonstrating the presence of twopyrimidines (cytosine and thymine) and two purines (adenine and guanine) in nucleicacids.1924. Feulgen, developing the fuchsin staining technique, showed that chromosomescontain DNA.1938. Behrens showed that most of the DNA is in the nucleus, and most of the RNA in thecytoplasm.1938. Astbury and Bell showed that the bases in a DNA molecule are stacked one abovethe other, and lie with their planes perpendicular to the long axis of the molecule.1944. Avery, MacLeod and McCarty presented first evidence that DNA is the geneticmaterial.1947. Chargaff showed that DNA contains equal proportions of purines and pyrimidines.1950. Wilkins and coworkers showed that the purine and pyrimidine bases are placedregularly along the DNA molecule at a distance of 3.4A. The molecules are twisted into ahelix with one complete turn every 34A.1952. Hershey and Chase showed that in the T2 virus DNA is the sole carrier of geneticinformation form parent to offspring.1953. Watson and Crick suggested the double helix modell.1960-ies. Deciphering the genetic code.2001-2003. Human genom sequence.
Ismert genom szekvenciákBacteria Haemophilus influenzae and Escherichia coliYeasts Saccharomyces cerevisiae and Schizosaccharomyces pombeNematode Caenorhabditis elegansFruit fly Drosophila melanogasterPlant Arabidopsis thalianaMouse Mus musculusHuman Homo sapiens
Page 2: A nukleinsavak monomerjeiDNSRNS
Page 6 and 7: A nukleinsavak primer szerkezete
Page 8 and 9: Oligo(poli)nukleotidkonformációCo
Page 10 and 11: A DNS szerkezeteX-ray diffraction p
Page 12 and 13: Bázispárok a DNS-ben (Watson-Cric
Page 14 and 15: A DNS szerkezet változataiB-forma
Page 16: DNS szuperszerkezetekSchematic illu
Page 19 and 20: Nukleinsavak szekvenálásaThe basi
Page 24: Purinok előállításabElektrofil
Page 27 and 28: Nukleozidok előállítása - Vorbr
Page 29: Nukleinsavak szintézise
Page 32 and 33: Nukleinsavak szintézise - capping
Page 34 and 35: Purinszármazékok és gyógyászat
Page 36 and 37: A fehérjeszintézisvázlataProtein
Page 38 and 39: A genetikai kód
Page 42: Nukleotidok egyéb funkciói

Nukleinsavak - Szerves Kémiai Tanszék

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