VILNIUS UNIVERSITY INSTITUTE OF BIOTECHNOLOGY ...

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The work presented in this doctoral dissertation has been carried out at the Institute of Biotechnologyfrom 2002 to 2006.Dissertation is maintained by externScientific consultant:Prof. Dr. habil. Saulius Klimašauskas (Institute of Biotechnology, physical sciences,biochemistry - 04 P, proteins, enzymology - P310)Evaluation board of dissertation of Biochemistry trend:Chairman:Members:Official opponents:Prof. Dr. habil. Kęstutis Sasnauskas (Institute of Biotechnology, physical sciences,biochemistry - 04 P, proteins, enzymology - P310)Prof. Dr. habil. Vida Kirvelienė (Vilnius University, physical sciences,biochemistry - 04 P,nucleic acids, protein synthesis - P320)Prof. Dr. habil. Eugenijus Butkus (Science Council of Lithuania, physical sciences, chemistry- 03 P, organic chemistry - P390)Dr. Rolandas Meškys (Institute of Biochemistry, physical sciences, biochemistry -04 P,proteins, enzymology - P310)Prof. Dr. habil. Virginijus Šikšnys (Institute of Biotechnology, physical sciences, biochemistry– 04 P, proteins, enzymology - P310)Prof. Dr. habil. Gervydas Dienys (Institute of Biotechnology, physical sciences, chemistry -03 P, organic chemistry - P390)Dr. habil. Narimantas Čėnas (Institute of Biochemistry, physical sciences, biochemistry - 04P, proteins, enzymology - P310)The thesis defense will take place at 1 p. m. on 12 th of October, 2007, at the Institute of Biotechnology.Address: Graičiūno 8, LT-02241, Vilnius, Lithuania.The abstract of the thesis was distributed on 3 rd of September, 2007.The thesis is available at the Library of Institute of Biotechnology and at the Library of VilniusUniversity.2
VILNIAUS UNIVERSITETASBIOTECHNOLOGIJOS INSTITUTASGražvydas LukinavičiusMETILTRANSFERAZIŲ KATALIZUOJAMAS FUNKCINIŲ GRUPIŲ ĮVEDIMASSPECIFINĖSE DNR SEKOSEDaktaro disertacijaFiziniai mokslai, biochemija (04 P), baltymai, enzimologija (P310)<strong>VILNIUS</strong>, 20073
Page 1: VILNIUS UNIVERSITYINSTITUTE OF BIOT
Page 5 and 6: CONTENTSCONTENTS ..................
Page 7 and 8: Specific aims:1. To chemically synt
Page 9 and 10: chloro-1-pentyne according to (Bran
Page 11 and 12: DNA protection assay for alkyltrans
Page 13 and 14: RESULTS AND DISCUSSION1 Design of n
Page 15 and 16: Chemical structure of the first ana
Page 17 and 18: purification and was therefore remo
Page 19 and 20: 3 Chemical stability of the AdoMet
Page 21 and 22: 4 Activity of AdoMet analogs in enz
Page 23 and 24: All mutant enzymes demonstrated an
Page 25 and 26: M.BcnIB matched the UV spectrum of
Page 27 and 28: Figure 18. Compositional analysis o
Page 29 and 30: Figure 20. Sequence-specific two-st
Page 31 and 32: 8 DiscussionDNA methyltransferases
Page 33 and 34: numbers with synthetic cofactors, s
Page 35 and 36: LIST OF PUBLICATIONS1. Dalhoff, C*.
Page 37 and 38: REZIUMĖGyvas organizmas yra sudėt
Page 39: 21. Merkiene, E. and S. Klimasauska

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