ANTIHISTAMINES - rEMERGs
ANTIHISTAMINES - rEMERGs
ANTIHISTAMINES - rEMERGs
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Physostigmine‣ Acetylcholinesterase inhibitor thus increases acethylcholine at synapse‣ Physostigmine is the ONLY agent that can cross the BBB for a central effect‣ Risk: can cause seizures; asystole reported after TCA ingestion;‣ Benefit: reverses delirium in 96% of patients thus is diagnostic and therapeutic‣ Dose: 1-2 mg iv and repeat prn‣ Contraindications: blocks on ECG (risk of asystole); suspected TCA ingestionDisposition: observe 4-6 hrs unless it is a delayed onset agent like Datura stramonium seeds
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