DuraGen Plus Brochure - Integra LifeSciences

Duraplasty solutionsfrom the leader inregenerative technologyThe optimized onlay dural graft.Engineered for performance.

The Dural Regeneration Matrixresorption rate matches thegrowth rate of new tissueThe most advancedDural Regeneration MatrixT=0 DaysX125T=1 DayX125DuraGen Plus ® meets the requirements of an onlayand delivers superior resultsT=12 DaysX250RequirementsUltra Pure CollagenExcellent ConformabilityOptimized ResorptionEngineered PorosityFunctionNo reported foreign body reaction,fibrin clot formation for biological sealEnsures graft approximation at the duralmarginMatrix resorbs at the same rate as newtissue formsFacilitates tissue integration, no reportedencapsulationT=60 DaysX250The Dural Regeneration Matrix is immediatelyinfiltrated by fibroblasts and is completely replacedwith endogenous tissue within 8 to 12 monthsIntegra Advanced BiomaterialsInnovation Timeline1970–1980’sCollagen MatrixDevelopment1985oral SurgeryCollaCote,® CollaPlug,®CollaTape® absorbabledental implants1994orthopedic SurgeryAbsorbable CollagenSponge with BoneGrowth Factor1995oral SurgeryBioMend,® guidedtissue regeneration

DuraGen Plus, safe and effective in over450,000 patientsDURAGEN PLUS,THE VERSATILE ONLAY GRAFT• Minimal adhesion formation only following significant disruptionof pia-arachnoid 1• Effective protection against CSF leakage with sutureless closure 1• No foreign body reactions or immune rejection reported 3-5Integra’s Dural Regeneration Matrix - 30 years ofscience, innovation, and application• Integra’s Ultra Pure Collagen technology is the basis of products usedby neuro, orthopedic, plastic & reconstructive, and oral surgeons 2• Integra’s Ultra Pure Collagen has been used in over 10 millionprocedures 2• Integra’s Ultra Pure Collagen is used to manufacture product forCranial applicationssome of the world’s largest medical device companies 2• Integra offers a complete set of neurosurgical solutions for the repairof dura mater (DuraGen Plus, Suturable DuraGen, and Endura)Integra...Driven by science.Delivering innovation.Spinal applications1996199920012002200320042005Burn surgeryIntegra ® DermalRegenerationTemplateNeurosurgeryDuraGen®Dural Graft Matrixoral SurgeryBioMend ExtendNeurosurgeryNeuraGen®Nerve GuidePlastic andReconstructiveIntegra BilayerMatrix WoundDressingNeurosurgeryDuraGen Plus®NeurosurgeryEnduraNo-React®Dural SubstituteNeurosurgeryNeuraWrapNerve ProtectorPlastic andReconstructiveIntegra MatrixWound DressingNeurosurgerySuturableDuraGen