Technical guidelines on testing the migration of primary aromatic ...
Technical guidelines on testing the migration of primary aromatic ...
Technical guidelines on testing the migration of primary aromatic ...
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1 PROTOCOL A BY LC-MS1.1 PrincipleThis method was elaborated and validated for those PAA´s being derived fromisocyanates listed in Directive 2002/72/EC and <strong>the</strong> following Directives. The methodcan be extended to amines <strong>of</strong> any o<strong>the</strong>r origin. This protocol has been validated byinterlaboratory comparis<strong>on</strong>s between Danish laboratories (Mortensen et al, 2005)and an EU validati<strong>on</strong> organized by BfR (report: 2009)1.2 Materials and ChemicalsNOTE: All reagents should be <strong>of</strong> recognised analytical quality unless o<strong>the</strong>rwise stated.1.2.1 Analytes and chemicals1.2.1.1 Methanol (pro analysis)1.2.1.2 Ethanol (absolute, pro analysis)1.2.1.3 Glass distilled water or purified water1.2.1.4 Pentafluoropropi<strong>on</strong>ic acid (PFPA), e.g. 97 %1.2.1.5 Glacial acetic acid, 100 % (pro analysis)1.2.1.6 Acet<strong>on</strong>e1.2.1.7 Analytical standards <strong>of</strong> <strong>the</strong> 20 PAATable 1: Analytical grade <strong>of</strong> <strong>the</strong> standards <strong>of</strong> <strong>the</strong> 20 PAAName(Abbreviati<strong>on</strong>)4-Aminobiphenyl(4-ABP)CAS No. Structure MW92-67-1 H 2 N169.2Purity98.4Aniline(ANL)NH 262-53-3 93.199o-Anisidine(o-ASD)NH 290-04-0 123.2O99+Benzidine(BNZ)92-87-5 H 2 N NH 2 184.299.54-Chloro-Aniline(4-CA)106-47-8 127.6ClNH 29823
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