Pharm D Revised Regulations 2008 - Rajiv Gandhi University of ...

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246 Dehydro halogenation of alkyl halides: 1,2 elimination, kinetics, E2 and E1mechanism, elimination via carbocation, evidence for E2 mechanism, absence ofrearrangement isotope effect, absence hydrogen exchange, the element effect,orientation and reactivity, E2 versus E1, elimination versus substitution,dehydration of alcohol, ease of dehydration, acid catalysis, reversibility,orientation.7 Electrophillic and free radicals addition: Reactions at carbon -carbon, doublebond, electrophile, hydrogenation, heat of hydrogenation and stability of alkenes,markownikoff rule, addition of hydrogen halides, addition of hydrogen bromides,peroxide effect, electrophillic addition, mechanism, rearrangement, absence ofhydrogen exchange, orientation and reactivity, addition of halogen, mechanism,halohydin formation, mechanism of free radicals additon, mechanism of peroxideinitiated addition of hydrogen bromide, orientation of free addition, additions ofcarbene to alkene, cyclo addition reactions.8 Carbon-carbon double bond as substituents: Free radical halogenations ofalkenes, comparision of free radical substitution with free radical addition, freeradical substitution in alkenes, orientation and reactivity, allylic rearrangements.9 Theory of resonance: Allyl radical as a resonance hybrid, stability, orbitalpicture, resonance stabilisation of allyl radicals, hyper conjugation, allyl cation asa resonance hybrid, nucleophyllic substitution in allylic substrate, SN1 reactivity,allylic rearrangement, resonance stabilisation of allyl cation, hyper conjugation,nucleophilic substitution in allylic substrate, SN2 nucleophilic substituion invinylic substrate, vinylic cation, stability of conjugated dienes, resonance inalkenes, hyper conjugation, ease of formation of conjugated dienes, orientation ofelimination, electrophilic addition to conjugated dienes, 1,4 - addition, 1,2-versus1,4-addition, rate versus equilibrium, orientation and reactivity of free radicaladdition to conjugated dienes.10 Elecrophilic aromatic substitution: Effect of substituent groups, determination oforientation, determination of relative reactivity, classification of substituentgroup, mechanism of nitration, sulphonation, halogenation, friedel craftalkylation, friedel craft acylation, reactivity and orientation, activating anddeactivating O,P,M directing groups, electron release via resonance, effect ofhalogen on electrophilic aromatic substitution in alkyl benzene, side chainhalogination of alkyl benzene, resonance stabilization of benzyl radical.11 Nucleophilic addition reaction: Mechanism, ionisation of carboxylic acids,acidity constants, acidity of acids, structure of carboxylate ions, effect ofsubstituent on acidity, nucleophilic acyl substitution reaction, conversion of acidto acid chloride, esters, amide and anhydride. Role of caboxyl group, comparisonof alkyl nucleophilic substitution with acyl nucleophilic substitution.
2512 Mechanism of aldol condensation, claisen condensation, cannizzaro reaction,crossed aldol condensation, crossed cannizzaro reaction, benzoin condensation,perkin condensation. Knoevenagel, Reformatsky reaction, Wittig reaction,Michael addition.13 Hoffman rearrangement: Migration to electr on deficient nitrogen, Sandmeyer’sreaction, basicity of amines, diazotisation and coupling, acidity of phenols,Williamson synthesis, Fries rearrangement, Kolbe reaction, Reimer tieman’sreactions.14 Nucleophilic aromatic substitution: Bimolecular displacement mechanisms,orientation, comparison of aliphatic nucleophilic substitution with that ofaromatic.15 Oxidation reduction reaction.16 Study of the following official compounds- preparation, test for purity, assay andmedicinal uses of Chlorbutol, Dimercaprol, Glyceryl trinitrate, Urea, Ethylenediamine dihyrate, Vanillin, Paraldehyde, Ethylene chloride, Lactic acid, Tartaricacid, citric acid, salicylic acid, aspirin, methyl salicylate, ethyl benzoate, benzylbenzoate, dimethyl pthalate, sodium lauryl sulphate, saccharin sodium,mephensin.1.4 PHARMACEUTICAL ORGANIC CHEMISTRY (PRACTICAL)Practical : 3 Hrs./WeekI. Introduction to the various laboratory techniques through demonstrationinvolving synthesis of the following compounds (at least 8 compounds to besynthesised):1. Acetanilde / aspirin (Acetylation)2. Benzanilide / Phenyl benzoate (Benzoylation)3. P-bromo acetanilide / 2,4,6 – tribromo aniline (Bromination)4. Dibenzylidene acetone (Condensation)5. 1-Phenylazo-2-napthol (Diazotisation and coupling)6. Benzoic acid / salicylic acid (Hydrolysis of ester)7. M-dinitro benzene (Nitration)8. 9, 10 – Antharaquinone (Oxidation of anthracene) / preparation of benzoic acidfrom toluene or benzaldehyde9. M-phenylene diamine (Reduction of M-dinitrobenzene) / Aniline fromnitrobenzene10. Benzophenone oxime11. Nitration of salicylic acid12. Preparation of picric acid13. Preparation of O-chlorobenzoic acid from O-chlorotolune14. Preparation of cyclohexanone from cyclohexanol
Page 1 and 2: 1RAJIV GANDHI UNIVERSITY OF HEALTH
Page 3 and 4: 3Second Year:S.No Name of Subject N
Page 5 and 6: Sixth Year:5Internship or residency
Page 7 and 8: 7Second Year examination :S.No. Nam
Page 9 and 10: 12. Declaration of Class9Class shal
Page 11 and 12: 11(v) Final evaluation of project w
Page 13 and 14: 4. Lecture wise program : Topics1 S
Page 15 and 16: 151.1 HUMAN ANATOMY & PHYSIOLOGY (P
Page 17 and 18: Theory : 2 Hrs. /Week171.2 PHARMACE
Page 19 and 20: 195. Linimentsa. Liniment of turpen
Page 21 and 22: 214 Lipid metabolism: Oxidation of
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Page 31 and 32: 311.6 REMEDIAL MATHEMATICS/BIOLOGY
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Page 35 and 36: 35- Amylodosis4 Cancer: differences
Page 37 and 38: 373. Detailed syllabus and lecture
Page 39 and 40: 392.3 PHARMACOGNOSY & PHYTOPHARMACE
Page 41 and 42: 41Theory : 3 Hrs. /Week2.4 PHARMACO
Page 43 and 44: 434. Pharmacology of drugs acting o
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Page 49 and 50: 49Third YearTheory : 3 Hrs. /Week3.
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Page 57 and 58: 57PracticalsTitle of the Experiment
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Page 61 and 62: 614. Pharmacy Act -1948.Objectives
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Page 67 and 68: 67Practical : 3 Hrs./Week4.1 PHARMA
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752.4 Statistical methods in epidem
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774.5 BIOPHARMACEUTICS AND PHARMACO
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79Fifth yearTheory : 3 Hrs. /Week5.
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815.2 PHARMACOEPIDEMIOLOGY AND PHAR
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83APPENDIX-BCONDITIONS TO BE FULFIL
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85Pharmacology or Pharmaceutics16.
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874. Director orPrincipal orHead of
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895) ACCOMMODATION :Suitable and su
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91II. Apparatus:S.No Name Minimum r
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938 Muffle Furnace 019 Mechanical S
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9537 Conical Percolator (glass/copp
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97F. DEPARTMENT OF PHARMACY PRACTIC
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99APPENDIX-CINTERNSHIP1) SPECIFIC O
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