03.12.2012 Views

veNTIlATIoN - Green Cross Publishing

veNTIlATIoN - Green Cross Publishing

veNTIlATIoN - Green Cross Publishing

SHOW MORE
SHOW LESS

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

Butrans ® patches contain an opioid analgesic<br />

PRESCRIBING INFORMATION<br />

BuTrans ® 5µg/h, 10µg/h and 20µg/h Transdermal Patch<br />

Presentation: BuTrans 5µg/h, 10µg/h, 20µg/h. Transdermal beige patches<br />

containing buprenorphine. Indications: Treatment of non-malignant pain of<br />

moderate intensity when an opioid is necessary for obtaining adequate<br />

analgesia. BuTrans is not suitable for the treatment of acute pain. Dosage and<br />

Administration: BuTrans should be administered every 7 days. Elderly and<br />

adults over 18 years only: Use the 5 µg/h patch for at least the first 3 days of<br />

treatment, before increasing the dose if necessary. Do not use more than two<br />

patches at a time. Contra-indications: Known buprenorphine or excipient<br />

hypersensitivity, opioid dependent patients, narcotic withdrawal treatment,<br />

respiratory depression, us e of MAO inhibitors within the past 2 weeks,<br />

myasthenia gravis, delirium tremens, pregnancy and lactation. Precautions<br />

and Warnings: Convulsive disorders, head injury, shock, reduced<br />

consciousness of uncertain origin, intracranial lesions or increased intracranial<br />

pressure, severe hepatic impairment, history of drug abuse. Not<br />

recommended immediately postoperatively or for situations characterised by<br />

a narrow therapeutic index or for rapidly varying analgesic requirements. May<br />

® Butrans is a Registered Trademark. © 2009 Napp Pharmaceuticals Limited. CODE 0924BTN. Date of item: April 2009<br />

days<br />

pain relief in<br />

one BuTrans patch<br />

BuTrans® matrix patches are Ireland’s first patches designed to provide 7 days’<br />

continuous relief from moderate osteoarthritis pain. Good news for doctors,<br />

good news for patients, good news for joints.<br />

affect ability to drive or use machinery. Interactions: Monoamine oxidase<br />

inhibitors (MAOIs), CNS depressants (e.g. benzodiazepines, opioid<br />

derivatives, antidepressants, sedatives, alcohol, anxiolytics, neuroleptics,<br />

clonidine). CYP 3A4 inhibitors and inducers, products reducing hepatic blood<br />

flow (e.g. halothane). Side Effects: Common: anorexia, confusion,<br />

depression, insomnia, nervousness, headache, dizziness, somnolence,<br />

paraesthesia, vasodilation, dyspnoea, constipation, dry mouth, nausea,<br />

vomiting, abdominal pain, diarrhoea, dyspepsia, sweating, tiredness, pain,<br />

peripheral oedema, application site reaction, chest pain, pruritus, erythema,<br />

rash, exanthema, asthenia. Potentially serious side effects also include: allergic<br />

reactions, psychotic disorder, hallucinations, nightmares, drug dependence,<br />

mood swings, dysarthria, migraine, syncope, visual disturbance, angina<br />

pectoris, palpitations, tachycardia, hypotension, hypertension, aggravated<br />

asthma, respiratory failure, diverticulitis, dysphagia, ileus, biliary colic,<br />

myalgia, depersonalisation, memory impairment, respiratory depression,<br />

urinary retention, decreased libido, pyrexia, rigors, alanine aminotransferase<br />

increased, drug withdrawal syndrome, abnormal coordination, circulatory<br />

collapse, wheezing. Please consult the SPC for details of other side-effects.<br />

Legal Category: CD (Sch2) POM. Package Quantities: 5 µg/h transdermal<br />

patch: 2 individually sealed patches. 10 µg/h transdermal patch: 4 individually<br />

sealed patches. 20 µg/h transdermal patch: 4 individually se aled patches.<br />

Marketing Authorisation Numbers: PA 913/24/1-3. Marketing<br />

7 7 Days’ Days’<br />

continuous continuous<br />

relief relief from from<br />

MODERATE MODERATE<br />

OSTEOARTHRITIS<br />

OSTEOARTHRITIS<br />

PAIN<br />

PAIN<br />

Not suitable for the treatment of acute pain.<br />

Authorisation Holder: Napp Pharmaceuticals Limited, Cambridge Science Park,<br />

Milton Road, Cambridge CB4 0GW, UK. Further information is available<br />

from: Mundipharma Pharmaceuticals Ltd, Millbank House, Arkle Road,<br />

Sandyford, Dublin 18. Tel: +353 (0)1 2063800. Member of the<br />

Mundipharma/Napp independent associated companies. Date of Preparation:<br />

February 2009.<br />

Adverse events should be reported to<br />

Mundipharma Pharmaceuticals Limited on (01) 206 3800<br />

When non-opioid analgesics aren’t enough

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!