Regulating particle morphology during a spray freeze drying ...

More documents

Recommendations

Info

Als Dissertation genehmigt durch die NaturwissenschaftlicheFakultät der Friedrich‐Alexander‐Universität Erlangen‐NürnbergTag der mündlichen Prüfung:Vorsitzender der Promotionskommission:Erstberichterstatter:Zweitberichterstatter:Prof. Dr. Eberhard BänschProf. Dr. Geoffrey LeeProf. Dr. Wolfgang Frieß
Page 1: REGULATING PARTICLE MORPHOLOGY DURI
Page 5 and 6: DanksagungDie vorliegende Arbeit wu
Page 7 and 8: Desweiteren möchte ich Anne Mundst
Page 9 and 10: TABLE OF CONTENTS ITable of content
Page 11 and 12: TABLE OF CONTENTS III5.1.4 HPLC‐C
Page 13 and 14: ABBREVIATIONS VList of abbreviation
Page 15 and 16: ABBREVIATIONS VIIExpressionsAF4APIb
Page 17 and 18: INTRODUCTION 11 IntroductionBiologi
Page 19 and 20: INTRODUCTION 3using pure protein so
Page 21 and 22: INTRODUCTION TO SPRAY FREEZE‐DRYI
Page 35 and 36: LIGHT‐SCATTERING 19perpendicular
Page 37 and 38: LIGHT‐SCATTERING 21of large parti
Page 39 and 40: LIGHT‐SCATTERING 23Equation 7. K
Page 41 and 42: LIGHT‐SCATTERING 25scattering ang
Page 43 and 44: LIGHT‐SCATTERING 273.2.4 Instrume
Page 45 and 46: LIGHT‐SCATTERING 29The fluctuatio
Page 47 and 48: LIGHT‐SCATTERING 313.2.6 Instrume
Page 49 and 50: LIGHT‐SCATTERING33samples correct
Page 51 and 52: MATERIAL AND METHODS 354 Material a
Page 53 and 54:
MATERIAL AND METHODS 37thereby prod
Page 55 and 56:
MATERIAL AND METHODS 394.1.1.3 L‐
Page 57 and 58:
MATERIAL AND METHODS 41Product Supp
Page 59 and 60:
MATERIAL AND METHODS 43was allowed
Page 61 and 62:
MATERIAL AND METHODS 45to 30 °C in
Page 63 and 64:
MMATERIAL AND METHODS47134a)2b)Figu
Page 65 and 66:
MATERIAL AND METHODS 49diluted to a
Page 67 and 68:
MATERIAL AND METHODS 51very fine po
Page 69 and 70:
RESULTS AND DISCUSSION 535 Results
Page 71 and 72:
RESULTS AND DISCUSSION 55parameters
Page 73 and 74:
RESULTS AND DISCUSSION 57Equation 2
Page 75 and 76:
RESULTS AND DISCUSSION 595.1.2 RI
Page 77 and 78:
RESULTS AND DISCUSSION 61For the on
Page 79 and 80:
RESULTS AND DISCUSSION 635.1.4 HPLC
Page 81 and 82:
RESULTS AND DISCUSSION 65Two more p
Page 83 and 84:
RESULTS AND DISCUSSION 67amino acid
Page 85 and 86:
RESULTS AND DISCUSSION 695.1.7 Prot
Page 87 and 88:
RESULTS AND DISCUSSION 715.1.8 A 2
Page 89 and 90:
RESULTS AND DISCUSSION73a)b)Figure
Page 91 and 92:
RESULTS AND DISCUSSION 75A 2 measur
Page 93 and 94:
RESULTS AND DISCUSSION 77a)b)Figure
Page 95 and 96:
RESULTS AND DISCUSSION 79Buffer‐l
Page 97 and 98:
RESULTS AND DISCUSSION 81Figure 54.
Page 99 and 100:
RESULTS AND DISCUSSION 83Figure 55.
Page 101 and 102:
RESULTS AND DISCUSSION 85mass deter
Page 103 and 104:
RESULTS AND DISCUSSION 87FTIR measu
Page 105 and 106:
RESULTS AND DISCUSSION 89decreased
Page 107 and 108:
RESULTS AND DISCUSSION 915.2.3.2 Th
Page 109 and 110:
RESULTS AND DISCUSSION 93Mc Coy and
Page 111 and 112:
RESULTS AND DISCUSSION95alsoa reduc
Page 113 and 114:
RESULTS AND DISCUSSION 97the surfac
Page 115 and 116:
RESULTS AND DISCUSSION99SFDwith the
Page 117 and 118:
RESULTS AND DISCUSSION101a)b)200 μ
Page 119 and 120:
RESULTS AND DISCUSSION 103a)Figure
Page 121 and 122:
RESULTS AND DISCUSSION 105observed
Page 123 and 124:
RESULTS AND DISCUSSION 107A satisfa
Page 125 and 126:
RESULTS AND DISCUSSION 109Therefore
Page 127 and 128:
RESULTS AND DISCUSSION 111UV‐meas
Page 129 and 130:
RESULTS AND DISCUSSION 113the addit
Page 131 and 132:
RESULTS AND DISCUSSION 1155.3.3.2 A
Page 133 and 134:
RESULTS AND DISCUSSION 117Figure 90
Page 135 and 136:
RESULTS AND DISCUSSION119a)50 μmb)
Page 137 and 138:
RESULTS AND DISCUSSION 1215.3.5 Sta
Page 139 and 140:
RESULTS AND DISCUSSION 123a)b)Figur
Page 141 and 142:
RESULTS AND DISCUSSION 125a) b)Figu
Page 143 and 144:
RESULTS AND DISCUSSION 127a)b)20 μ
Page 145 and 146:
RESULTS AND DISCUSSION 129a)b)Figur
Page 147 and 148:
RESULTS AND DISCUSSION 131actuated
Page 149 and 150:
RESULTS AND DISCUSSION 133[Rochelle
Page 151 and 152:
RESULTS AND DISCUSSION 135excipient
Page 153 and 154:
RESULTS AND DISCUSSION 1375.3.5.1.4
Page 155 and 156:
RESULTS AND DISCUSSION 139a) b)100
Page 157 and 158:
RESULTS AND DISCUSSION 141No T g
Page 159 and 160:
RESULTS AND DISCUSSION 143Figure 11
Page 161 and 162:
RESULTS AND DISCUSSION 145shows the
Page 163 and 164:
RESULTS AND DISCUSSION 1475.4 Lacta
Page 165 and 166:
RESULTS AND DISCUSSION 149potassium
Page 167 and 168:
Page 169 and 170:
RESULTS AND DISCUSSION 153The sampl
Page 171 and 172:
RESULTS AND DISCUSSION 1555.5 Regul
Page 173 and 174:
Page 175 and 176:
RESULTS AND DISCUSSION 159a)20 μmb
Page 177 and 178:
RESULTS AND DISCUSSION 161Step Onse
Page 179 and 180:
RESULTS AND DISCUSSION 163particles
Page 181 and 182:
RESULTS AND DISCUSSION165a)50 μmb)
Page 183 and 184:
RESULTS AND DISCUSSION 167Levi and
Page 185 and 186:
RESULTS AND DISCUSSION 169distribut
Page 187 and 188:
RESULTS AND DISCUSSION 1715.5.2.2 C
Page 189 and 190:
RESULTS AND DISCUSSION 173generatio
Page 191 and 192:
CONCLUSIONS 1756 ConclusionsThis th
Page 193 and 194:
CONCLUSIONS 177distinct increase in
Page 195 and 196:
CONCLUSIONS 179powder particles wer
Page 197 and 198:
ZUSAMMENFASSUNG 181Zusammensetzung
Page 199 and 200:
ZUSAMMENFASSUNG 183Restaktivität v
Page 201 and 202:
ZUSAMMENFASSUNG 185Die Frage war nu
Page 203 and 204:
REFERENCES 187[Baynes et al. 2005][
Page 205 and 206:
REFERENCES 189monoclonal antibody.
Page 207 and 208:
REFERENCES 191[Fraunhofer and Winte
Page 209 and 210:
REFERENCES 193conformation formed i
Page 211 and 212:
REFERENCES 195[Maa et al. 1997][Maa
Page 213 and 214:
REFERENCES 197[Ohgushi and Wada 198
Page 215 and 216:
REFERENCES 199[Prins et al. 1998][R
Page 217 and 218:
REFERENCES 201[Tang et al. 2006]Tan
Page 219 and 220:
REFERENCES 203[Whitesides et al. 20
Page 221 and 222:
REFERENCES 205[Ziegler et al. 2010]
show all

Regulating particle morphology during a spray freeze drying ...

Create successful ePaper yourself

Delete template?

Save as template?