Single dose oral diclofenac for acute postoperative pain in adults

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different ways of analysing and presenting results. Pain2005;116(3):322–31. [DOI: 10.1016/j.pain.2005.05.001]Morris 1995Morris JA, Gardner MJ. Calculating confidence intervalsfor relative risk, odds ratio and standardised ratios and rates.In: Gardner MJ, Altman DG editor(s). Statistics withconfidence - confidence intervals and statistical guidelines.London: British Medical Journal, 1995:50–63.Oldman 2000Oldman A, Smith LA, Collins S, Carroll D, Wiffen PJ,McQuay HJ, et al.Single dose oral aspirin for acute pain.Cochrane Database of Systematic Reviews 2000, Issue 2.[DOI: 10.1002/14651858.CD002067]PACT 2007Prescription Cost Analysis . England 2007. [ISBN:978–1–84636–210–1]Rapoport 1999Rapoport RJ. The Safety of NSAIDs and Related Drugsfor the Management of Acute Pain: Maximizing Benefitsand Minimizing Risks. Cancer Control 1999;6(2 Suppl 1):18–21.Roy 2007Roy YM, Derry S, Moore RA. Single dose orallumiracoxib for postoperative pain. Cochrane Databaseof Systematic Reviews 2007, Issue 4. [DOI: 10.1002/14651858.CD006865]Toms 2008Toms L, McQuay HJ, Derry S, Moore RA. Single dose oralparacetamol (acetaminophen) for postoperative pain inadults. Cochrane Database of Systematic Reviews 2008, Issue4. [DOI: 10.1002/14651858.CD004602]Tramèr 1997Tramèr MR, Reynolds DJM, Moore RA, McQuay HJ.Impact of covert duplicate results on meta-analysis: a casestudy. BMJ 1997;315:635–9.References to other published versions of this reviewBarden 2004aBarden J, Edwards J, Moore RA, McQuay HJ. Single doseoral diclofenac for postoperative pain. Cochrane Databaseof Systematic Reviews 2004, Issue 2. [DOI: 10.1002/14651858.CD004768]Collins 1998Collins SL, Moore RA, McQuay HJ, Wiffen PJ. Oralibuprofen and diclofenac in postoperative pain: aquantitative systematic review. European Journal of Pain1998;2(4):285–91.∗ Indicates the major publication for the studySingle dose oral diclofenac for acute postoperative pain in adults (Review)Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.24
C H A R A C T E R I S T I C S O F S T U D I E SCharacteristics of included studies [ordered by study ID]Ahlstrom 1993MethodsParticipantsRCT, DB, double dummy, single oral dose, 3 parallel groupsMedication administered when baseline pain was of moderate to severe intensityPain assessed at 0, 20, 40, 60 mins then hourly up to 6 hoursThird molar extractionN = 97M = 46, F = 51Mean age 25 yrsInterventions Diclofenac (soluble) 50 mg, n = 35Ibuprofen (tablets) 400 mg, n = 32Placebo, n = 30OutcomesNotesPI: std 100 mm VASPR: std 100 mm VASPGE: std 5 point scaleOxford Quality Score: R1, DB2, W1No details about rescue medication used or any restrictions on time before use was permittedBakshi 1992MethodsParticipantsRCT, DB, single dose, 3 parallel groupsMedication administered when baseline pain was of moderate to severe intensityPain assessed at 0, 15, 30 and 60 mins then hourly up to 6 hoursThird molar extractionN = 151M = 70, F = 81Mean age 26 yrsInterventions Diclofenac K 50 mg, n = 51Diclofenac Na (enteric coated) 50 mg, n = 54Placebo, n = 46OutcomesNotesPI: std 4 point scalePR: 4 point scale (non std)PGE: 4 point scale (non std)Oxford Quality Score: R1, DB1, W1Rescue medication permitted after 1 hour. No details about drug usedSingle dose oral diclofenac for acute postoperative pain in adults (Review)Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.25
Page 3 and 4: [Intervention Review]Single dose or
Page 5: (baseline observation carried forwa
Page 8 and 9: In the 15 included studies, a total
Page 10 and 11: • The proportion of participants
Page 12 and 13: Figure 4.Forest plot of comparison:
Page 14 and 15: Figure 6.Forest plot of comparison:
Page 16 and 17: (Continued)Dental surgery 100mgOthe
Page 18 and 19: (2.3 to 3.5).Summary of results C:
Page 20 and 21: Any adverse event• Four studies u
Page 22 and 23: 2.3 for at least 50% pain relief co
Page 24 and 25: of teeth. Journal of the Dental Ass
Page 28 and 29: Bakshi 1994MethodsParticipantsRCT,
Page 30 and 31: Herbertson 1995MethodsParticipantsR
Page 32 and 33: Kubitzek 2003(Continued)NotesOxford
Page 34 and 35: Torres 2004(Continued)All MMean age
Page 36 and 37: (Continued)Rautela 1998Shimura 1981
Page 38 and 39: 3.2 Diclofenac K 6 591 Risk Ratio (
Page 40 and 41: Analysis 2.2.Comparison 2 Diclofena
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Page 56 and 57: Appendix 4. GlossaryCategorical rat
Page 58: S O U R C E S O F S U P P O R TInte

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