Single dose oral diclofenac for acute postoperative pain in adults

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Herbertson 1995MethodsParticipantsRCT, DB, 4 parallel groups, single oral doseMedication administered when baseline pain was of moderate to severe intensityPain assessed at 0, 30 and 60 mins, then hourly to 8 hours.Gynaecological surgeryN = 217All FMean age = 43 yrsInterventions Diclofenac K 50 mg, n = 52Diclofenac K 100 mg, n = 52Aspirin 650 mg, n = 53Placebo, n =52OutcomesNotesPI: std 4 point scalePR: std 5 point scalePGE: std 5 point scaleOxford Quality Score: R1, DB1, W1Rescue medication permitted after 1 hour, but 2 hours recommended. No details of drug usedHersh 2004MethodsParticipantsRCT, DB, double dummy, 4 parallel groups, single oral doseMedication administered when baseline pain was of moderate to severe intensityPain assessed at 0, 15, 30, 45, 60, 90, 120 mins, then hourly to 6 hoursThird molar extractionN = 265M = 111, F = 154Mean age 21 yrsInterventions Diclofenac K 25 mg, n = 63Diclofenac K 50 mg, n = 68Diclofenac K 100 mg, n = 66Placebo, n = 68OutcomesNotesPI: std 4 point scalePR: std 5 point scalePGE: std 5 point scaleNumbers using rescue medicationTime to use of rescue medicationNumbers with any adverse eventWithdrawalsOxford Quality Score: R2, DB2, W1Rescue medication permitted after 1 hour (hydrocodone/paracetamol 5/500 mg or oxycodone/paracetamol 5/325mg)Single dose oral diclofenac for acute postoperative pain in adults (Review)Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.28
Hofele 2006MethodsParticipantsRCT, DB, double dummy, 3 parallel groups, single oral doseMedication administered when baseline pain was of moderate to severe intensityPain assessed at 0, 15, 30, 45, 60, 90, 120 mins, then hourly to 6 hours, and at 8 and 24 hoursThird molar extractionN = 184M = 85, F = 99Mean age = 27 yrsInterventions Diclofenac K sachet 50 mg, n = 74Diclofenac K tablet 50 mg, n = 71Placebo, n = 39OutcomesNotesPI: std 4 point scalePR: std 5 point scalePGE: std 5 point scaleNumbers using rescue medicationTime to use of rescue medicationNumbers with any adverse eventWithdrawalsOxford Quality Score: R2, DB2, W1Rescue medication permitted after 2 hours (paracetamol 1000 mg)Kubitzek 2003MethodsParticipantsRCT, DB, 3 parallel groups, single oral doseMedication administered when baseline pain was of moderate to severe intensityPain assessed at 0, 30, 60 mins, then hourly to 6 hoursThird molar extractionN = 245M = ~40%, F = ~60%Age not givenInterventions Diclofenac K 25 mg, n = 83Paracetamol 1000 mg, n = 78Placebo, n = 84OutcomesPI: std 4 point scalePR: std 5 point scalePGE: std 5 point scaleNumbers using rescue medicationTime to use of rescue medicationNumbers with any adverse event and serious adverse eventsWithdrawalsSingle dose oral diclofenac for acute postoperative pain in adults (Review)Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.29
Page 3 and 4: [Intervention Review]Single dose or
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Page 8 and 9: In the 15 included studies, a total
Page 10 and 11: • The proportion of participants
Page 12 and 13: Figure 4.Forest plot of comparison:
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Page 16 and 17: (Continued)Dental surgery 100mgOthe
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Page 28 and 29: Bakshi 1994MethodsParticipantsRCT,
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Page 56 and 57: Appendix 4. GlossaryCategorical rat
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Single dose oral diclofenac for acute postoperative pain in adults

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