Single dose oral diclofenac for acute postoperative pain in adults

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Table 2. Summary of outcomes: adverse events and withdrawals(Continued)Cooper1996(1) Diclofenac Na50 mg, n = 18(2) Misoprostol 200µg, n = 21(3) Diclofenac Na +misoprostol 50 mg/200 µg, n = 20(4) Placebo, n = 11No usable data. AllAEs were transientand mild, and considerednormal sequaleof surgical procedureand probablyunrelated to studydrugNoneDesjardins 2004(1) Diclofenac Na100 mg, n = 85(2) Rofecoxib 50mg, n = 85(3) Placebo, n = 82at 24 hours:(1) 38/85(3) 41/82None (1) 1/85(3) 3/82None reportedHerbertson 1994 (1) Diclofenac K 50mg, n = 52(2) Diclofenac K100 mg, n = 52(3) Aspirin 650 mg,n = 53(4) Placebo, n = 52Hersh 2004 (1) Diclofenac K 25mg, n = 63(2) Diclofenac K 50mg, n = 68(3) Diclofenac K100 mg, n = 66(4) Placebo, n = 68(1) 6/54(2) 6/55(4) 2/54(1) 8/63(2) 8/68(3) 7/66(4) 9/68None 8 in total In total, 8 participantsdid not contributeto any efficacyanalysis, 23 didnot contribute to reportedTOTPAR 8None reported None 1 placebo participantunwilling tocontinueHofele 2006(1) Diclofenac K sachet50 mg, n = 74(2) Diclofenac Ktablet 50 mg, n = 71(3) Placebo, n = 39at 8 hours:(1) 2/74(2) 2/71(3) 2/39None None 5 exclusions for protocolviolations:2 diclofenac sachet,1 diclofenac tablet, 1placeboKubitzek 2003 (1) Diclofenac K 25mg, n = 83(2) Paracetamol1000 mg, n = 78(3) Placebo, n = 84at 48 hrs:(1) 6/83(3) 2/84None None 1 placebo participantexcluded forprotocol violationMehlisch 1994 (1) Diclofenac K 50mg, n = 53(2) Diclofenac K100 mg, n = 52(3) Aspirin 650 mg,n = 51at 7 days:(1) 5/53(2) 8/52(4) 4/52None None None reportedSingle dose oral diclofenac for acute postoperative pain in adults (Review)Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.50
Table 2. Summary of outcomes: adverse events and withdrawals(Continued)(4) Placebo, n = 52Nelson 1994 (1) Diclofenac K 25mg, n = 50(2) Diclofenac K 50mg, n = 50(3) Diclofenac K100 mg, n = 50(4) Aspirin 650 mg,n = 50(5) Placebo, n = 50Olson 1997 (1) Diclofenac K 25mg, n = 52(2) Diclofenac K 50mg, n = 50(3) Diclofenac K100 mg, n = 51(4) Aspirin 650 mg,n = 50(5) Placebo, n = 52Torres 2004 (1) Diclofenac SR 75mg, n = 68(2) Valdecoxib 20mg, n = 68(3) Valdecoxib 40mg, n = 69(4) Placebo, n = 67at 8 hours:(1) 5/51(2) 4/51(3) 4/51(5) 6/51at 8 hours:(1) 1/52(2) 0/50(3) 1/51(5) 1/52at 12 hours:(1) 14/65(4) 17/67None reported None 1 participantexcluded fromsafety analysis, 3 excludedfrom any efficacyanalysis, 7 excludedfrom 8 hourefficacy analysisNone None NoneNone reported No usable data No usable dataZuniga2004(1) Diclofenac K100 mg, n = 31(2) Diclofenac Nasoftgel 100 mg, n =29(3) Placebo, n = 15at 24 hours:(1) 5/31(2) 5/29(3) 1/15most occurred afterrescue medicationNone None 1 participantexcluded due to protocolviolationSingle dose oral diclofenac for acute postoperative pain in adults (Review)Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.51
Page 3 and 4: [Intervention Review]Single dose or
Page 5: (baseline observation carried forwa
Page 8 and 9: In the 15 included studies, a total
Page 10 and 11: • The proportion of participants
Page 12 and 13: Figure 4.Forest plot of comparison:
Page 14 and 15: Figure 6.Forest plot of comparison:
Page 16 and 17: (Continued)Dental surgery 100mgOthe
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Page 20 and 21: Any adverse event• Four studies u
Page 22 and 23: 2.3 for at least 50% pain relief co
Page 24 and 25: of teeth. Journal of the Dental Ass
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Page 28 and 29: Bakshi 1994MethodsParticipantsRCT,
Page 30 and 31: Herbertson 1995MethodsParticipantsR
Page 32 and 33: Kubitzek 2003(Continued)NotesOxford
Page 34 and 35: Torres 2004(Continued)All MMean age
Page 36 and 37: (Continued)Rautela 1998Shimura 1981
Page 38 and 39: 3.2 Diclofenac K 6 591 Risk Ratio (
Page 40 and 41: Analysis 2.2.Comparison 2 Diclofena
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Page 50 and 51: Table 1. Summary of outcomes: analg
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Page 56 and 57: Appendix 4. GlossaryCategorical rat
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Single dose oral diclofenac for acute postoperative pain in adults

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