Single dose oral diclofenac for acute postoperative pain in adults

Analysis 3.2.Comparison 3 Diclofenac 100 mg v placebo, Outcome 2 Participants with at least 50% painrelief over 4 to 6 hours, dental or other surgery.Review:Single dose oral diclofenac for acute postoperative pain in adultsComparison:3 Diclofenac 100 mg v placeboOutcome:2 Participants with at least 50% pain relief over 4 to 6 hours, dental or other surgeryStudy or subgroup Diclofenac 100 Placebo Risk Ratio Weight Risk Ratio1 Dental surgeryn/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CIHersh 2004 52/66 11/68 24.4 % 4.87 [ 2.80, 8.49 ]Mehlisch 1995 35/52 4/52 9.0 % 8.75 [ 3.35, 22.86 ]Nelson 1994 35/50 4/50 9.0 % 8.75 [ 3.36, 22.79 ]Zuniga 2004 16/29 0/8 1.7 % 9.90 [ 0.66, 149.25 ]Zuniga 2004 13/31 0/7 1.8 % 6.75 [ 0.45, 101.88 ]Subtotal (95% CI) 228 185 46.0 % 6.65 [ 4.34, 10.21 ]Total events: 151 (Diclofenac 100), 19 (Placebo)Heterogeneity: Chi 2 = 1.92, df = 4 (P = 0.75); I 2 =0.0%Test for overall effect: Z = 8.67 (P < 0.00001)2 Other surgeryDesjardins 2004 13/85 4/82 9.2 % 3.14 [ 1.07, 9.22 ]Herbertson 1995 29/52 5/52 11.3 % 5.80 [ 2.44, 13.81 ]Olson 1997 37/51 15/52 33.5 % 2.52 [ 1.59, 3.98 ]Subtotal (95% CI) 188 186 54.0 % 3.31 [ 2.24, 4.88 ]Total events: 79 (Diclofenac 100), 24 (Placebo)Heterogeneity: Chi 2 = 2.99, df = 2 (P = 0.22); I 2 =33%Test for overall effect: Z = 6.02 (P < 0.00001)Total (95% CI) 416 371 100.0 % 4.85 [ 3.63, 6.47 ]Total events: 230 (Diclofenac 100), 43 (Placebo)Heterogeneity: Chi 2 = 11.88, df = 7 (P = 0.10); I 2 =41%Test for overall effect: Z = 10.71 (P < 0.00001)Test for subgroup differences: Chi 2 = 5.61, df = 1 (P = 0.02), I 2 =82%0.05 0.2 1 5 20Favours experimentalFavours controlSingle dose oral diclofenac for acute postoperative pain in adults (Review)Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.41