Southern Medical and Surgical Journal - Georgia Regents University

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1849.] O'Keeffe, on the Propej^ties of Dogwood. Bark.that of the branches ;the size of the tree, and thickness of thebark, also contribute to augment the amount of extract obtained.In evaporating the decoctions to the consistence directed, themore quickly the process is conducted, the better ;for thus, theduration of exposure to the prejudicial influence of the atmosphere,is diminished.Care must be taken in distilling the alcoholfrom the tincture, that the preparation sustain no injury byadherence to the bottom and sides of the apparatus—an accidenta|)t to occur, if the process be prolonged beyond the prescribedlimits ; should the latter take place, the distillation willhave been continued to dryness, and the extract burned.Greatcaution must be observed in conducting the evaporation of boththe inspissated fluids. To prevent the prepar'ation being burnedduring the latter stage of the process, it will be necessary toremove it from the fire, and complete the evaporation in anopen vessel over a slow fire, at the same time keeping it frequentlystirred.the bark.The use of alcohol is indispensable for extracting thej^esin ofThe boiling may be repeated until the bark is entirelydevoid of bitterness, which result we have noticed after thesecond boiling.From ten pounds of bark we obtained fifteenounces of extract, yielding the proportion of an ounce and a halfto a pound. The average consumption of alcohol is a pint tothe ounjce and a half of extract.To the adept in Pharmacy, a descent into so minute a specificationof directions and precautions is inapplicable; they aresimply the facts v;hich experience has furnished us, and aresolely intended to direct subsequent experimenters, who, deemingthe subject worthy of their consideration, may be inducedto adopt our formula in its preparation.In the hands of otherpractitioners, its success may be equivocal: if so, we have nohesitation in attributing its failure to the absence of the necessarycare in conducting the process.Medical properties and uses. At this early period of its existence,it would be un philosophical to venture upon a delineationof the precise modus operandi of this remedy upon thesystem in a pathological state. For, although its eflfects invarious morbid conditions have palpably, and repeatedly, beenmanifested, and might have aflbrded data, upon which to erect
10 0'Keeffe,onthePrope7*tiesofDogttJOodBa?'k. [January,a comely theoretical superstructure—destined, perhaps, ere^long, to be sapped by some successful revolutionist— still, far beit from our purpose, to launch out unsupported into the voidrealms of hypothesis, and revel in the short lived glories of aprecocious and presumptuous speculation; but content ourselveswith confining our statements within the limits of mere fact, norbe obnoxious to the charges emanating from the variedinterpretationof results, consequent upon the disparity of humanopinions. The discrepancy existing, even at this advanced stageof its history, regarding the effects of Quinine on the animaleconomy, alone might warn us of so perilous an adventure.general, and in spme cases, a profuse perspiration,Ahas been themost obvious of its sensible effects; its astringency may be setdown as well authenticated, from facts which will be presentedin their proper place ; some patients have declared that it produced" ringing in the ears," &c., but such we regard as illfounded,and attributable rather to the agency of a morbidimagination.Of its alleged tendency to irritate the intestinal canal, enoughhas been said, we trust, to satisfy the most skeptical mind ; sofar from producing any unpleasant effects in the stomach, orbowels, diarrhoeas, when occurring as complications in intermittentfever, have, not unfrequently, been arrested under itsadministration.Notwithstanding our confidence of its applicability under allcircumstances, where an anti-febrile remedy is indicated, wewould not be understood as denying the existence of gastric disorderin evei-y case in which it has been used. Such an assertionwould be equivolcnt to the annihilationof a symptom themost uniform in a febrile paroxysm, viz., vomiting; and thecandid practitioner will be free to admit the peculiar embarrassmentpresented in the treatment by this distressing accident.The writer, anxious to ascerj:ain with precision the effects oflarge doses of the extract on the system in a physiological state,has instituted the following experiment upon himself10, A. M. 1st dose, 30 grs. Ext. ;pulse previous to taking it, 72.11. 2nd dose, 30 grs. ;pulse intermittent, 72-70 ; temperatureof surface somewhat augmented ;general perspiration ; asense of fullness and slight dull pain over the frontal eminences,
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Page 33 and 34: —American Medical Association.[Ja
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——so Monthly Periscope. [Januar
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§2 Monthly Periscope.— Medical I
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; 1164 Medical Intelligence. -Meteo
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Southern Medical and Surgical Journal - Georgia Regents University

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