1849.] O'KeefFe, on the Properties of Dogwood Bark. 19system to these periodic invasions, the inferences rationally deduciblefrom the general properties of the Ext. of Dogwoodbark are—that with antiperiodic, it combines tonic virtues,therefore its effects on the system are more permanent thanthose of quinine, to which modern observation will not ascribethese properties in so high a degree ;that by imparting tone tothe system, it secures a more favourable <strong>and</strong> fortified conditionof the organs for resisting the subsequent encroachments of themorbific agent ;<strong>and</strong> consequently, may not this latter qualificationgive it an important advantage over quinine, inasmuch asit is calculated to accomplish /?er se, w'hat would require quinine,"with a course of tonic treatment?A few cases could be adduced in support of the positionhere suggested, Which Will be adverted to en passant; but tosubstantiate <strong>and</strong> mature such a proposition, would dem<strong>and</strong> theevidence of protracted experience. And should subsequentobservation add confirmation to the truth of the foregoing suggestion,the profession will have attained the link which nowseems deficient in the chain of ratdical treatment ofparoxysmalfever.Case No. 3, presents but little variation from the two pre--ceding cases, only being complicated by anasarca, which wasa peculiarly distressing accident. The connection between theparoxysms <strong>and</strong> the local affection is shown by the subsidenceof the latter, without any local application, on the arrest of theformer. The second administration of the Ext. Cor. preventeda return of the exacerbation.Case IV. F. C, a mechanic, set. 32, residence on the;canal—intemperate habits. On the 10th July, he was takenwith a chill succeeded by fever.- 12th, second paroxysm, <strong>and</strong>on the 14th, third paroxysm. It is proper to remark, that atthistime, he was convalescing from some hepatic affection ofthree weeks continuance, manifested by anicterodestateof theskin, <strong>and</strong> slight tenderness on pressure, over the liver <strong>and</strong> stomach.16th, 7, P. M. First visit—found him in the sweating stageof a paroxysm, which came on about 12, M., to-day ; the tongueis coated, <strong>and</strong> red ; breath offensive ;great tenderness on pres-
:60 O'KeefFe, on the Properties of Dogwood Bark. [January,sure over the epigastric, <strong>and</strong> right hypochondriac regions; alsoover the dorsal vertebrae. Sinapism, to the epigastrium <strong>and</strong>dorsal spine; Cal. 20grs., Jal. 10 grs.; S grs. Ext. Cor.atl.A.M. 18th, repealed every hour until AQ grs. are taken.19th, 4, P. M. Prescription followed ; had a paroxysm yesterdayabout 3, P. M. Mitigated in all the symptoms, <strong>and</strong> ofshorter duration than the preceding; has had several stools ;tenderness over the liver relieved ; is free from fever, but therebeing anorexia <strong>and</strong> much debility, has kept his bed all day.8 grs. Ext. Cor. at 7, A. M. 20th, repeated every hour till 64 grs.are taken.21st. Took 64 grs. Ext. Cor. ; missed the paroxysm ; localpains <strong>and</strong> tenderness all disappeared ; appetite <strong>and</strong> colour ofskin much improved. Convalescence was rapid, notwithst<strong>and</strong>ingthe protracted illness.Case V. Phil, a negro, rail-road h<strong>and</strong>, aged 29, strong constitution,occupation a blacksmith, had a chill 12, M., 9th Sept.,attended with vomiting, diarrhoea <strong>and</strong> griping pain in the bowels.10th. Had the second chill about 12, M., diarrhoea <strong>and</strong>griping pain persistent.11th, 10, A.M. First saw him—has no fever, but is mUchexhausted; diarrhoea <strong>and</strong> pain in the bowels most prominentsymptoms. Prescribed: Cal. <strong>and</strong> Dover's powd., aa 15 grs.;20 grs. Ext. Cor. every hour till 60 grs. are taken.3, P. M. Paroxysm returned at 12, M. ; has taken all themedicine ; has slight fever now ; no vomiting ; diarrhoea <strong>and</strong>griping pain relieved—the former completely checked. Infusionof salts <strong>and</strong> senna to-night.12th, 41, P. M. Has taken the salts <strong>and</strong> senna; several copiousstools; has no f^weY, no pain—feels much better, butweak. 12 grs. Ext. Cor. at 7, to-morrow morning, repeatedevery hour till 60 grs. are taken.13th, 4, P. M. Took the Ext. Cor., which produced slightvertigo ; no fever—convalescent.Case VL S. L., a white girl, aged 9 years, of delicate habit5th Sept., had the first paroxysm ;6th, chill at 10, A. M.7th, 11, A. M. First visit—found the pulse excited; skin
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