Nuclide Imaging: Planar Scintigraphy, SPECT, PET - Polytechnic ...

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• Nuclide Imaging OverviewLecture Outline• Review of Radioactive Decay• Planar Scintigraphy– Scintillation camera– Imaging equation• Single Photon Emission Computed Tomography(SPECT)• Positron Emission Tomography (PET)• Image Quality consideration– Resolution, noise, SNR, blurringEL5823 Nuclear Imaging Yao Wang, Polytechnic U., Brooklyn 2
What is Nuclear Medicine• Also known as nuclide imaging• Introduce radioactive substance intobody• Allow for distribution anduptake/metabolism of compound⇒ Functional Imaging!• Detect regional variations ofradioactivity as indication ofpresence or absence of specificphysiologic function• Detection by “gamma camera” ordetector array• (Image reconstruction)From H. Graber, Lecture Note for BMI1, F05EL5823 Nuclear Imaging Yao Wang, Polytechnic U., Brooklyn 3
Page 1: Nuclide Imaging: PlanarScintigraphy
Page 5 and 6: What is Radioactivity?EL5823 Nuclea
Page 7 and 8: Gamma Decay (Isometric Transition)
Page 9 and 10: Radioactive Decay Law• N(t): the
Page 11 and 12: Overview of Imaging Modalities• P
Page 13 and 14: Anger Scintillation CameraCompare t
Page 15 and 16: • Scintillation crystal:Scintilla
Page 17 and 18: Inside a Photomultiplier Tube10^6-1
Page 19 and 20: Pulse Height CalculationEL5823 Nucl
Page 21 and 22: Acquisition ModesEL5823 Nuclear Ima
Page 23 and 24: Single Frame ModeThe value in each
Page 25 and 26: Multiple Gated AcquisitionEL5823 Nu
Page 27 and 28: Imaging EquationEL5823 Nuclear Imag
Page 29 and 30: Examples• Example 1: Imaging of a
Page 31 and 32: SPECT Instrumentation• Similar to
Page 33 and 34: Imaging Equation: θ=0(z,l)RReplace
Page 35 and 36: General Case: Imaging EquationEL582
Page 37 and 38: Correction for Attenuation Factor
Page 39 and 40: SPECT applications• Brain:- Perfu
Page 41 and 42: Annihilation Coincidence Detection
Page 43 and 44: Coincidence TimingEL5823 Nuclear Im
Page 45 and 46: Multiple Ring DetectorEL5823 Nuclea
Page 47 and 48: A Typical PET ScannerEL5823 Nuclear
Page 49 and 50: Imaging EquationNNN+−c( s )( s )(
Page 51 and 52: Reconstruction from Corrected Sinog
Page 53 and 54:
PET resolution compared to MRIPET
Page 55 and 56:
PET applications• Brain:- Tumor d
Page 57 and 58:
Image Quality Consideration• We w
Page 59 and 60:
Collimator ResolutionRc(z)2* Rc(z)
Page 61 and 62:
Intrinsic ResolutionE) dz’ }EL582
Page 63 and 64:
Detector EfficiencyEL5823 Nuclear I
Page 65 and 66:
Summary• Three major imaging moda
Page 67:
Homework• Reading:- Prince and Li
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