Nuclide Imaging: Planar Scintigraphy, SPECT, PET - Polytechnic ...

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Combined PET/CT Systems• CT: provides high resolution anatomical information• PET: Low resolution functional imaging• Traditional approach:– Obtain CT and PET images separately– Registration of CT and PET images, to help interpretation of PETimages• Combined PET/CT: Performing PET and CTmeasurements within the same system without movingthe patient relative to the table– Make the registration problem easier– But measurement are still taken separately with quite long timelagEL5823 Nuclear Imaging Yao Wang, Polytechnic U., Brooklyn 48
Imaging EquationNNN+−c( s )( s )( s )0⎪⎧ R⎪⎫= N0exp⎨− ∫ µ ( x(s'),y(s'));E)ds'⎬⎪⎩ s⎪0⎭s0⎪⎧ ⎪⎫= N0exp⎨− ∫ µ ( x(s'),y(s'));E)ds'⎬⎪⎩ −R⎪ ⎭⎪⎧ R⎪⎫= N0exp⎨− ∫ µ ( x(s'),y(s'));E)ds'⎬⎪⎩ s⎪0⎭s0⎪⎧ ⎪⎫• exp⎨− ∫ µ ( x(s'),y(s'));E)ds'⎬⎪⎩ −R⎪ ⎭R⎧ ⎫= N0exp⎨− ∫ µ ( x(s'),y(s'));E)ds'⎬⎩ −R⎭00RRRR⎪⎧⎪⎫⎪⎧⎪⎫ϕ(l,θ ) = K∫A(x(s),y(s))exp⎨−∫µ ( x(s'),y(s'))ds'⎬ds= K∫A(x(s),y(s))ds • exp⎨−∫ µ ( x(s'),y(s'))ds'⎬−R⎪⎩ −R⎪⎭ −R⎪⎩ −R⎪ ⎭A(x,y)and µ(x,y) can be separated!EL5823 Nuclear Imaging Yao Wang, Polytechnic U., Brooklyn 49
Page 1 and 2: Nuclide Imaging: PlanarScintigraphy
Page 3 and 4: What is Nuclear Medicine• Also kn
Page 5 and 6: What is Radioactivity?EL5823 Nuclea
Page 7 and 8: Gamma Decay (Isometric Transition)
Page 9 and 10: Radioactive Decay Law• N(t): the
Page 11 and 12: Overview of Imaging Modalities• P
Page 13 and 14: Anger Scintillation CameraCompare t
Page 15 and 16: • Scintillation crystal:Scintilla
Page 17 and 18: Inside a Photomultiplier Tube10^6-1
Page 19 and 20: Pulse Height CalculationEL5823 Nucl
Page 21 and 22: Acquisition ModesEL5823 Nuclear Ima
Page 23 and 24: Single Frame ModeThe value in each
Page 25 and 26: Multiple Gated AcquisitionEL5823 Nu
Page 27 and 28: Imaging EquationEL5823 Nuclear Imag
Page 29 and 30: Examples• Example 1: Imaging of a
Page 31 and 32: SPECT Instrumentation• Similar to
Page 33 and 34: Imaging Equation: θ=0(z,l)RReplace
Page 35 and 36: General Case: Imaging EquationEL582
Page 37 and 38: Correction for Attenuation Factor
Page 39 and 40: SPECT applications• Brain:- Perfu
Page 41 and 42: Annihilation Coincidence Detection
Page 43 and 44: Coincidence TimingEL5823 Nuclear Im
Page 45 and 46: Multiple Ring DetectorEL5823 Nuclea
Page 47: A Typical PET ScannerEL5823 Nuclear
Page 51 and 52: Reconstruction from Corrected Sinog
Page 53 and 54: PET resolution compared to MRIPET
Page 55 and 56: PET applications• Brain:- Tumor d
Page 57 and 58: Image Quality Consideration• We w
Page 59 and 60: Collimator ResolutionRc(z)2* Rc(z)
Page 61 and 62: Intrinsic ResolutionE) dz’ }EL582
Page 63 and 64: Detector EfficiencyEL5823 Nuclear I
Page 65 and 66: Summary• Three major imaging moda
Page 67: Homework• Reading:- Prince and Li

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