Neuroendocrine Tumors of the Pancreas

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PanNEN: WHO 20041. Well-differentiated neuroendocrine tumorBenign: confined to pancreas, < 2 cm in size, nonangioinvasive,= 2 mitoses/10HPF and = 2% Ki-67-positive cellsFunctioning: insulinomaNonfunctioningBenign or low grade malignant (uncertain malignant potential):confined to pancreas, = 2 cm in size, > 2 mitoses/10HPF,> 2% Ki-67-positive cells, or angioinvasiveFunctioning: gastrinoma, insulinoma, VIPoma, glucagonoma,somatostatinoma or ectopic hormonal syndromeNonfunctioning2. Well-differentiated neuroendocrine carcinomaLow grade malignant: invasion of adjacent organs and/or metastasesFunctioning: gastrinoma, insulinoma, glucagonoma, VIPoma,somatostatinoma or ectopic hormonal syndromeNonfunctioning3. Poorly differentiated neuroendocrine carcinomaHigh grade malignantProf. Dr. med. P. KomminothZürich, Switzerlandvery difficult to apply in biopsies
Prof. Dr. med. P. KomminothZürich, Switzerland
Page 1 and 2: Neuroendocrine Tumors of thePancrea
Page 4 and 5: PanNEN: Clinical classification•F
Page 6 and 7: PanNEN: Distribution300250Insulinom
Page 8 and 9: What do the clinicians want from us
Page 10 and 11: Prof. Dr. med. P. KomminothZürich,
Page 20 and 21: LipaseProf. Dr. med. P. KomminothZ
Page 22 and 23: Acinar cell carcinoma• Pancreas s
Page 28 and 29: Solid-pseudopapillary tumor• 1-2%
Page 32 and 33: Solid-pseudopapillary tumor• CK (
Page 36 and 37: Pancreatoblastoma• squamoid corpu
Page 38 and 39: Pancreatoblastoma• CK + (but not
Page 42 and 43: WHO 2010• Categories for NEN:1. N
Page 44 and 45: What do the clinicians want from us
Page 48 and 49: (somatostatin)(peptide receptor rad
Page 50 and 51: ENETS TNM TNM UICC/AJCC 20102006200
Page 52 and 53: ENETS and AJCC/UICC TNM are differe
Page 56 and 57: WHOTNMTumortypeGrade&StagingBiopsie
Page 58 and 59: Syndromic PanNENPancreatic Tumors
Page 60 and 61: many chromosomesinvolvedboth gains
Page 62 and 63: cDNA expression arraySpearman 3fach
Page 64 and 65: 10 PanNEN -> genome widesequencing:
Page 66 and 67: Perren et al. unpublished dataALT:
Page 68 and 69: number of samples252015105Daxx and
Page 70 and 71: Genes and pathways alterations in P
Page 74 and 75: Questions ?Prof. Dr. med. P. Kommin
Page 76: WHO 2004 + CK19Tumor Percent specif

Neuroendocrine Tumors of the Pancreas

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