Neuroendocrine Tumors of the Pancreas
Neuroendocrine Tumors of the Pancreas
Neuroendocrine Tumors of the Pancreas
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DAXX ATRX-> DAXX ATRX probably late event• only in PanNEN <strong>of</strong> MEN1 larger (>3 cm)• nearly one-quarter <strong>of</strong> <strong>the</strong> sporadicPanNEN have dual mutations in MEN1and ei<strong>the</strong>r ATRX or DAXX• G2/M checkpoint dysfunction is neededin ALT cellsPr<strong>of</strong>. Dr. med. P. KomminothZürich, Switzerland
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