Neuroendocrine Tumors of the Pancreas

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Genes and pathways alterations in PanNENmTOR pathwayEGFRIGFRpredictive markers !IRS1ATRXPI3K* PTEN +MENINDAXXATMTargetedtherapyAktTSC1TSC2*VHL*HIF1Chromatin assembly andhistone remodellingProf. Dr. med. P. KomminothZürich, SwitzerlandGβLmTORRaptorCell proliferationHypoxiaNo targeted therapyPARP inhibitors (poly ADP ribose polymerase) ?Chk1 inhibitors (checkpoint kinase-1) ?
Prof. Dr. med. P. KomminothZürich, Switzerland
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Neuroendocrine Tumors of thePancrea
Page 4 and 5:
PanNEN: Clinical classification•F
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PanNEN: Distribution300250Insulinom
Page 8 and 9:
What do the clinicians want from us
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Prof. Dr. med. P. KomminothZürich,
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Page 16 and 17:
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Page 20 and 21: LipaseProf. Dr. med. P. KomminothZ
Page 22 and 23: Acinar cell carcinoma• Pancreas s
Page 24 and 25: Prof. Dr. med. P. KomminothZürich,
Page 28 and 29: Solid-pseudopapillary tumor• 1-2%
Page 32 and 33: Solid-pseudopapillary tumor• CK (
Page 36 and 37: Pancreatoblastoma• squamoid corpu
Page 38 and 39: Pancreatoblastoma• CK + (but not
Page 40 and 41: PanNEN: WHO 20041. Well-differentia
Page 42 and 43: WHO 2010• Categories for NEN:1. N
Page 44 and 45: What do the clinicians want from us
Page 48 and 49: (somatostatin)(peptide receptor rad
Page 50 and 51: ENETS TNM TNM UICC/AJCC 20102006200
Page 52 and 53: ENETS and AJCC/UICC TNM are differe
Page 56 and 57: WHOTNMTumortypeGrade&StagingBiopsie
Page 58 and 59: Syndromic PanNENPancreatic Tumors
Page 60 and 61: many chromosomesinvolvedboth gains
Page 62 and 63: cDNA expression arraySpearman 3fach
Page 64 and 65: 10 PanNEN -> genome widesequencing:
Page 66 and 67: Perren et al. unpublished dataALT:
Page 68 and 69: number of samples252015105Daxx and
Page 74 and 75: Questions ?Prof. Dr. med. P. Kommin
Page 76: WHO 2004 + CK19Tumor Percent specif
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Neuroendocrine Tumors of the Pancreas

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