Neuroendocrine Tumors of the Pancreas

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Prof. Dr. med. P. KomminothZürich, SwitzerlandSummary• PanNEN diagnosis may be challenging inFNA´s and biopsy cylinders• Rule out acinar cell carcinoma and solidpseudopapillarytumor• New WHO and TNM will help tostandardize diagnostics and treatment• Grading (MiB1) crucial for therapeuticdecision making in advanced PanNET• Increasing significance of pedictiveIHC markers for therapy (mTOR pathway)
ThanksProf. Dr. med. P. KomminothZürich, SwitzerlandA. Perren and his groupP. Saremaslani, S. SchmidE.J. Speel, J. ZhaoG. Klöppel, M. AnlaufPh. U. Heitz, J. Rothmany others
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Neuroendocrine Tumors of thePancrea
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PanNEN: Clinical classification•F
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PanNEN: Distribution300250Insulinom
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What do the clinicians want from us
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Prof. Dr. med. P. KomminothZürich,
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LipaseProf. Dr. med. P. KomminothZ
Page 22 and 23: Acinar cell carcinoma• Pancreas s
Page 24 and 25: Prof. Dr. med. P. KomminothZürich,
Page 28 and 29: Solid-pseudopapillary tumor• 1-2%
Page 32 and 33: Solid-pseudopapillary tumor• CK (
Page 36 and 37: Pancreatoblastoma• squamoid corpu
Page 38 and 39: Pancreatoblastoma• CK + (but not
Page 40 and 41: PanNEN: WHO 20041. Well-differentia
Page 42 and 43: WHO 2010• Categories for NEN:1. N
Page 44 and 45: What do the clinicians want from us
Page 48 and 49: (somatostatin)(peptide receptor rad
Page 50 and 51: ENETS TNM TNM UICC/AJCC 20102006200
Page 52 and 53: ENETS and AJCC/UICC TNM are differe
Page 56 and 57: WHOTNMTumortypeGrade&StagingBiopsie
Page 58 and 59: Syndromic PanNENPancreatic Tumors
Page 60 and 61: many chromosomesinvolvedboth gains
Page 62 and 63: cDNA expression arraySpearman 3fach
Page 64 and 65: 10 PanNEN -> genome widesequencing:
Page 66 and 67: Perren et al. unpublished dataALT:
Page 68 and 69: number of samples252015105Daxx and
Page 70 and 71: Genes and pathways alterations in P
Page 74 and 75: Questions ?Prof. Dr. med. P. Kommin
Page 76: WHO 2004 + CK19Tumor Percent specif
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Neuroendocrine Tumors of the Pancreas

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