Impact on Patient Care
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Penicillin-Resistant Pneumococcus Model of evoluti<strong>on</strong> indicates a slow emergencephase followed by an exp<strong>on</strong>ential growth phase of10 years reaching a stati<strong>on</strong>ary phase when PRP =50% Primary mechanism of resistance is alteredPBP’s, not by producti<strong>on</strong> of -lactamase-lactamase inhibitors do not affect thesusceptibility of these strainsJ Antimicrob Chem 1997;40 (Suppl A):11-1828