Impact on Patient Care

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Strategies for Overcoming ResistanceAvoid exclusive use patterns Use broad-spectrum agents appropriately– Induces resistance– Facilitates cross-resistance– Sustains organism in genesis environment New Drug Development– Do they contribute to the problem?32
Strategies for Overcoming Resistance Rotate agents Alternate between classes rather thanbetween agents within the class Shorten courses rather than lengthen Use targeted regimens as soon assusceptibility tests are available(bb guns, not shotguns)NEJM 1994;330:1240-4133
Page 1 and 2: Update on Antibacterial Resistance<
Page 3 and 4: Bad Bugs—No Drugs!2 M people will
Page 5 and 6: Major Factors Contributing to theEm
Page 7 and 8: Historical Perspective Until 1989 v
Page 9 and 10: 400 + Hospitals21% Teaching79% Comm
Page 11 and 12: Escherichia coli Leading nosocomial
Page 13 and 14: A.R.M. Program: Escherichia coli(20
Page 15 and 16: Klebsiella pneumoniae Resistance ca
Page 17 and 18: Pseudomonas aeruginosa Inducible, c
Page 19 and 20: Gram-Positive OrganismsIf We Only K
Page 21 and 22: A.R.M. Program: Staph aureus(2000-2
Page 23 and 24: Vancomycin ResistantStaphylococcus
Page 25 and 26: % macrolide resistanceRelationship
Page 27 and 28: A.R.M. Program: Enterococcus faeciu
Page 29 and 30: A.R.M. Program: Streptococcus pneum
Page 31: Preventing ResistanceUnrealistic pa
Page 35: Changing the Paradigm: What does th
Page 45 and 46: Program InformationA.R.M. ProgramPa

Impact on Patient Care

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