Impact on Patient Care

Historical Perspective Until 1989 vancomycin resistance had not beenreported; Antibacterial-containing In 1994 14% of hospital-acquiredsoapsenterococci -Meta-analysis were of 27 resistant studies between to vancomycin1980-2006(32% as of 2003) - MMWR 1993;42:597-99-soaps containing triclosan(0.1%-0.45%) were no more effectivethan plain soap in preventing illness and reducing bacterial levels Not on the confined hands to bacteria - Candida sp.-several J Clin Microbiol studies showed 1994;32:1092-98 evidence of triclosan-adapted crossresistance to antibioticsCID 2007 (September) :45:S137-147 Also seen with mupirocin - JAC 2003; 51:613-17 Vancomycin-dependent Enterococci (VDE) – EID 2004;10(7):1277-817