How to handle liver biopsy specimens
Prof B Portmann 11.20 - Virtual Pathology at the University of Leeds
Prof B Portmann 11.20 - Virtual Pathology at the University of Leeds
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Structural antigens<br />
• Cy<strong>to</strong>keratins 7,19 [AE1/AE3] = biliary epithelium<br />
• Cy<strong>to</strong>keratins 8, 18 / ‘Hepa<strong>to</strong>cyte-specific<br />
antigen’(HePar1) = hepa<strong>to</strong>cytes<br />
• CD68, HLA-DR = Kupffer cells<br />
• FVIII-associated Ag, CD34 = negative on normal<br />
sinusoidal endothelium<br />
• CD10, CD13, pCEA = canalicular regions<br />
Enzymes<br />
• Gamma-glutamyl-transpeptidase (γ GT)<br />
• Bile salt export protein (BSEP)<br />
• Multidrug resistance 3 (MDR3)
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