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NJCC Volume 10, Oktober 2006

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netherlands journal of critical care<br />

Conclusion<br />

Fluids are commonly given to prevent deterioration of renal function<br />

in hypovolaemia, sepsis, contrast nephropathy and administration<br />

of nephrotoxins. Summarising the current evidence, no clear highgrade<br />

recommendation can be given regarding the type of hydration<br />

regimen. Crystalloids appear to be safe in many settings, but exert<br />

less volume effect and may aggravate extravascular oedema. On the<br />

other hand, HES exerts larger volume effect, but caution is warranted<br />

when using high molecular weight HES with a higher degree of substitution<br />

as they may impair renal function. Albumin appears to be<br />

safe with regard to renal function.<br />

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552<br />

neth j crit care • volume 10 • no 5 • october 2006

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