Yttrium-90 and Rhenium-188 Radiopharmaceuticals for Radionuclide Therapy

0.8M CMPO in n-dodecane was used as the carrier. For solvent impregnation,
PTFE supports were cut to the diameter of the glass cell and kept immersed in the
solvent overnight. Before use, they were washed with deionized water and tightly
assembled into the generator set-up. The PC88A based SLM was inserted and
tightly fixed in between the first and second compartment. In the same way, the
CMPO impregnated PTFE was inserted and tightly fixed between the third and
fourth compartments. The generator was housed in a polymethyl methacrylate
box inside a fume hood to protect from any radioactivity contamination. The first
compartment was filled with 5 mL of 0.1M HNO 3 containing a 90 Sr/ 90 Y mixture
(pH1–2), the second compartment was filled with 5 mL of 4M HNO 3 , the third
compartment was filled with 5 mL of 4M HNO 3 and the fourth compartment was
filled with 5 mL of 1M acetic acid. To introduce the solution into the chamber
or collect the liquid product from the chamber, Teflon tubes of small diameter,
~2 mm were connected between the chambers, as shown in Fig. 14.1. The
solutions in the chambers were stirred using PTFE coated magnetic stirring bars.
The generator set-up was placed on the magnetic stirring system. The system was
run at different activity levels of 5, 20, 50 and 100 mCi. The SLM based 90 Sr/ 90 Y
generator system for 100 mCi levels in a semiautomation sequential mode was
developed to produce highly pure 90 Y that can be used in the preparation of
radioimmunoconjugates and radiopharmaceuticals.
FIG. 14.1. General scheme of the 90 Sr/ 90 Y generator using SLM technology.
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