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well-established pro-survival cellular pathway<br />
called autophagy. The Stressosome therefore<br />
unmasks the alternative role for autophagy in<br />
facilitating cell death. With this research we<br />
are trying to identify the proteins which make<br />
up the Stressosome and identify their role in<br />
the formation of the complex as well as in<br />
activating cell death. We are also examining<br />
the alternative mode of cell death that is<br />
activated by the Stressosome and trying to<br />
understand its importance in the context of<br />
life and death decisions in cancer cells. We<br />
believe that detailed investigation of these<br />
cellular phenomena can bring advances in our<br />
understanding of the cell death process and<br />
its regulation. Such studies may highlight novel<br />
targets that are important in cancer and allow<br />
us to determine the therapeutic potential of<br />
Stressosome signalling.’<br />
discovery Ireland 78,79<br />
This project is part of a wider body of work<br />
being undertaken in NUIG on mechanisms of<br />
cell death and survival. Another Ph.D student<br />
in the group, Karolina Pakos-Zebrucka, is<br />
investigating the cell signalling that leads to<br />
formation of this protein complex. Indeed, as<br />
her doctoral work has progressed, Ms. Koryga
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