BIOT

4:00 217. Optimization of mAb charge and size variants separation using dual pH/salt gradient elution IEC.
Y.F. Lee, S. Kluters, F. Wittkopp, C. Frech
4:20 218. Evaluation of cation exchange chromatography resin lot variability and optimization of process
conditions for the intermediate purification of a fusion protein. A. Slocum, K. Sterl, R. Wright
4:40 219. Knob-hole assembly of bispecific antibodies from half-antibodies. A.J. Williams
Westin San Diego
Diamond I
Biomolecular & Biophysical Processes
Protein Therapeutics: Formulation & Delivery
Section C
B. Hackel, J. Kaar, Organizers
E. Y. Chi, H. Samra, Organizers, Presiding
2:00 220. Characterization of highly concentrated mAb solution: One step towards the prediction of longterm
stability. M. Schermeyer, A.K. Wöll, J. Hubbuch
2:20 221. Predicting high-concentration antibody interactions with coarse-grained molecular modeling. C.
Calero-Rubio, R. Ghosh, A. Saluja, C.J. Roberts
2:40 222. Evaluation of pH-responsive hydrogel networks as oral delivery systems for hematologic factor IX.
S. Horava, K. Moy, J. Liou, N. Peppas
3:00 223. How predictive are protein-protein interactions of elevated viscosity for protein solutions. M.A.
Woldeyes, C. Calero-Rubio, E.M. Furst, C.J. Roberts
3:20 Intermission.
3:40 224. Protein-excipient interaction hotspots: In silico method development and Fab case study. T.S.
Barata, P. Dalby, S. Brocchini, M. Zloh
4:00 225. Electrospun nanofibers of gelatin/cyclodextrin and their potential application as hydrophobic drug
delivery system. A. Laha, S. Majumdar, C. Sharma
4:20 226. Effects of small molecule co-solutes on the viscosity and stability of highly concentrated solutions
of monoclonal antibodies. B. Dear, J. Hung, A. Borwankar, T. Truskett, K.P. Johnston
4:40 227. Accelerating pharmaceutical development: Case studies with automated approaches and
formulation ‘miniaturization’. R. Rajan, V. Razinkov, C. Ren, P. Yeh
Westin San Diego
Opal
Emerging Technologies
Section D