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Westin San Diego Emerald Ballroom Downstream Processes Disruptive BioProcessing for Upstream & Downstream Processes J. Neville, A. Noyes, T. M. Przybycien, Organizers K. Brower, J. P. Pieracci, Organizers, Presiding M. J. Betenbaugh, A. E. Schmelzer, Presiding 5:00 Panel Discussion. MONDAY MORNING Section A Westin San Diego Crystal II Upstream Processes Mammalian Cell Culture Process Development M. R. Antoniewicz, M. A. Blenner, N. Lewis, B. Mulukutla, V. Roy, Organizers P. Apostolidis, C. Metallo, Organizers, Presiding 8:30 73. Distinct metabolic states support pluripotent stem cell self-renewal. M. Badur, H. Zhang, A. Divakaruni, S. Parker, C. Jaeger, K. Hiller, A. Murphy, C. Metallo 8:50 74. 3M purification solution for mycoplasma retention. D.V. Smirnov, N. Stepanova, G.M. Jellum 9:10 75. Transcriptome analysis of Chinese hamster ovary (CHO) cell lines under low temperature conditions using RNA-seq. Y. Gowtham, C. Saski, S.W. Harcum 9:30 76. Process intensification through integration of upstream perfusion cell culture with downstream continuous chromatography in monoclonal antibody production. A. Castan, T. Falkman, E. Fäldt, L. Blomqvist, A. Forss 9:50 Intermission. 10:10 77. Increasing diversity of production cell lines through miniaturization, automation, and highthroughput analytics. K. Le, H. Victor, K. Daris, T. Munro 10:30 78. Automatic bioreactor feeding: Moving forward with metabolic activity monitoring for nutrient feeding. G. Emmerson, S. Watts, G. Barringer 10:50 79. Using a CFD model to better understand and optimize cell culture performance using the ambr15 reactor. W.J. Kelly, X. Li, Z. Huang, E.J. Schaefer, S. Subramanian
11:10 80. Cell death during production of biologics and its consequences on release of the intracellular contents. M. Krajcovic, S. Hutchins, K. Aron, M.C. Borys, Z. Li Westin San Diego Emerald Ballroom Downstream Processes Advances in Chromatographic Separations Section B J. Neville, A. Noyes, T. M. Przybycien, Organizers S. M. Cramer, J. Pollard, Organizers, Presiding 8:30 81. Evaluation of novel adsorptive hybrid filters for impurity removal during biologics purification. N. Singh, A. Arunkumar, M. Peck, A. Voloshin, J.F. Hester 8:50 82. Maximizing productivity with AEX membrane adsorbers: Impact on robustness and edge of failure. W. Rayfield, D.J. Roush, A. Gospodarek, M. Brower, C. Cutler, N. Tugcu 9:10 83. Evaluation of ligand design for downstream processes: Application to aggregate removal. J.K. Rasmussen, C. Bothof, G. Griesbraber, A. Vail, S. Colak Atan, F. Sgolastra 9:30 84. Developing high performance responsive HIC membrane adsorbers. Z. Liu, X. Qian, R. Wickramasinghe 9:50 Intermission. 10:10 85. Breaking through the productivity barrier: Integration of a novel modular chromatography scaffold and a new resin design to achieve a hyper-productive Protein A capture process. M. Siwak, G. de los Reyes, R. Todd 10:30 86. Insight into the profile of associated HCP with protein A resin cycle number. K. Lintern, M. Pathak, A.S. Rathore, D.G. Bracewell 10:50 87. Evaluation of excipients and cleaning solutions to enhance the performance of Protein A media. A. Becerra-Arteaga, A. Gupta 11:10 88. Best of both worlds: High affinity and structural stability in 3D-structured synthetic ligands for protein purification by affinity chromatography. S. Menegatti Westin San Diego Diamond I&II Biomolecular & Biophysical Processes Protein Engineering & Design Section C
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Page 11 and 12: 10:10 100. Comprehensive bioconvers
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Page 19 and 20: 9:10 177. Rethinking affibody: Evol
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Page 31 and 32: 338. Chromatographic depth filters:
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Page 35 and 36: 409. Mapping the collective respons
Page 37 and 38: Section C Westin San Diego Diamond
Page 39 and 40: 11:05 455. Use of quality by design
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Page 43 and 44: 2:20 496. Process linkage approach
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