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Westin San Diego Opal Emerging Technologies Protein & Molecular Engineering J. Latone, G. M. Thurber, I. R. Wheeldon, Organizers R. Bott, M. Kim, Organizers, Presiding 2:00 487. Artificial TCA cycle metabolon: Direct evidence for metabolon formation and substrate channeling. K. Garcia, B. Bulutoglu, F. Wu, S.D. Minteer, S. Banta 2:20 488. Osteogenic differentiation of stem cells promoted by the assemblies of genetically engineered bacteriophage. C. Mao 2:40 489. Bacterial inner membrane display for screening a naïve antibody library to isolate antibodies that bind survivin. P. Moghaddam-Taaheri, A.J. Karlsson 3:00 490. Rational design and development of polysialic acid-binding peptides: Implications in neural stem cell purification. D. Shastry, P. Karande 3:20 Intermission. 3:40 491. Constructing new bioluminescent tools with minimally perturbed luciferins. C.M. Rathbun, R.C. Steinhardt, W.B. Porterfield, K. Jones, D. McCutcheon, M.A. Paley, J.A. Prescher 4:00 492. Circle Akt In: Macrocycles against phosphorylated Akt. A. Nag, S. Das, J.R. Heath 4:20 493. Switchable protein sensors and enzyme reactions based on dynamic DNA assembly. R.P. Chen, D. Blackstock, Q. Sun, W. Chen 4:40 494. RNA length affects form and function of the Type I CRISPR-Cas surveillance complex. M. Luo, C. Beisel Westin San Diego Crystal I Quality by Design for Biopharmaceuticals QbD Case Studies: Process Validation Section E S. Singh, C. Torigoe, Organizers K. A. Barnthouse, M. T. Schmidt, Organizers, Presiding 2:00 495. Manufacturability assessment tool for effective decision-making and efficient process development: Development and applications. K. Brower, R.A. Patil, D.A. Shah, J. Walther, N.M. Troccoli, T.A. Vetter, V. Warikoo
2:20 496. Process linkage approach for establishing critical quality attribute target ranges. S. Khoo, M. Mun, M.T. Schmidt 2:40 497. Use of relevant process history for the determination of critical process parameters. B. Huffman, J. Cundy, K. Sunasara 3:00 498. Using characterization data to support process validation: A Monte Carlo approach. C. Thompson, T. Linke, A. Hunter, G. Miro-Quesada, X. Wang 3:20 Intermission. 3:40 499. Defining process design space for a therapeutic monoclonal antibody: Clearance of phospholipase B-Like 2 (PLBL2), a CHO host-cell protein impurity, by hydrophobic interaction chromatography. A. Sanchez, J. Bill, S. Fisher 4:00 500. Multivariate process monitoring towards enhanced continued process verification. C. Undey, S. Oruklu, B. Looze, C. Garvin 4:20 501. Designing resin end of lifetime studies and their application in the three stages of process validation. A. Magill, E.S. Wilhelm, J. Weiss, D. Saini 4:40 502. Improving the control strategy of legacy products using quality by design principles. D. Vu, A. Hagstrom, G. Miro-Quesada, G. Ferreira WEDNESDAY EVENING Westin San Diego Crystal II Biotechnology & Bioengineering Daniel IC Wang Award Section A T. M. Przybycien, P. M. Tessier, S. A. Tobler, Organizers, Presiding 5:00 Biotechnology & Bioengineering Daniel IC Wang award presentation. THURSDAY MORNING Westin San Diego Crystal II Upstream Processes Engineering Natural Products Biosynthesis Section A
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Page 3 and 4: 9:10 19. Imaging the oxidation stat
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Page 7 and 8: 3:40 61. Genome-scale engineering i
Page 9 and 10: 11:10 80. Cell death during product
Page 11 and 12: 10:10 100. Comprehensive bioconvers
Page 13 and 14: Microbial Process Development M. R.
Page 15 and 16: 4:40 142. Evolving an intrinsically
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Page 19 and 20: 9:10 177. Rethinking affibody: Evol
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Page 23 and 24: 4:00 217. Optimization of mAb charg
Page 25 and 26: 3:40 238. Application biophysical t
Page 27 and 28: 267. Gamma-aminobutyric acid produc
Page 29 and 30: 302. Inference of cohort-specific H
Page 31 and 32: 338. Chromatographic depth filters:
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Page 35 and 36: 409. Mapping the collective respons
Page 37 and 38: Section C Westin San Diego Diamond
Page 39 and 40: 11:05 455. Use of quality by design
Page 41: 4:00 476. Investigation of low mole
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Page 47 and 48: 10:10 Panel Discussion. Section F W
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