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391. Spectroscopy as a PAT tool for impurity detection and adaptive process control in downstream bioprocessing. S. Parimal, T. Brantley, L. Conley 392. Engineering affinity, selectivity and elutability into peptides for their development as ligands for downstream bioprocessing of non-mAb biologics. D. Chandra, S. Timmick, N. Vecchiarello, C. Goodwine, S.M. Cramer, P. Karande 393. Integrated fabrication-conjugation approach for biopolymeric-synthetic hybrid polymeric microspheres with improved protein conjugation capacity and kinetics via robust micromolding and bioorthogonal click reactions. S. Jung, H. Yi 394. Tailoring continuous protein A mAb capture for facility fit and process economics. X. Gjoka, K. Rogler, M. Bisschops, R. Gantier, M. Schofield 395. Enhanced bioadsorption of rare earth elements through cell surface display of lanthanide binding tag. D.M. Park, M. Yung, A. Eslamimanesh, D.W. Reed, Y. Fujita, A.M. Anderko, Y. Jiao 396. QSAR models for prediction of chromatographic behavior of homologous Fab variants. J. Robinson, H. Karkov, J. Woo, B.O. Krogh, H. Ahmadian, S.M. Cramer 397. Dynamic modeling of human coagulation cascade using reduced order effective kinetic models. A. Sagar 398. Polymer grafting to functionalize chromatography media for purification of monoclonal antibodies. J.U. Hansson, E. Brekkan, J. Bengtsson 399. Recombinant DNA and its medical benefits: Synthesis of insulin. B.B. Ibrahim 400. New enabling technologies for continuous final formulation of mAbs. E. Ayturk 401. Analyzing the mechanical properties of three synthetic based biopolymers. R. Anderson 402. Evaluation of flow-through hydrophobic interaction and hydroxyapatite chromatography steps for the removal of aggregates in the purification of monoclonal antibody TBL-mAb-01. W. Evans, A. Chakrabarti 403. Capturing carbon dioxide in hydroxyacid-derived bio-plastics. I.s. Al Rowaihi, S. Groetzinger, K. Dietrich, J. Eppinger 404. Single-molecule kinetics of protein adsorption on thin nylon 6,6 films. H. Shen, L.J. Tauzin, W. Wang, B. Hoener, L. Kisley, A. Hoggard, C.F. Landes 405. More affordable version of therapeutic protein recombinant Streptokinase to address over a million ST elevated Micardial Infarction (STEMI) deaths in part of the world where affordibility is the key. D. Ghosh, S. Paul, R.K. Gupta 406. Improving the alkali stability of the kappa light chain-binding polypeptide from domain of peptostreptococcus protein L. R. Palmgren, G. Rodrigo, A. Mattsson, T. Bjorkman, J. Vasic, E. Monie, M. Ander, G. Bauren 407. Keynote: Emerging technologies. E. Shusta 408. Optimum pulse mode selection for biodiesel production using ultrasound irradiations. E. Martinez- Guerra, V. Gude
409. Mapping the collective response of water to predict biomolecular interaction interfaces. R.C. Remsing, J.D. Weeks 410. Molecular dynamics simulations of proteins coupled to nanoparticles. S. Sen, P. Kral 411. Withdrawn. 412. Moving towards a sterile chromatography platform for virus purification. J. Konietzko, S. Wang, A. Kristopeit, M. Wenger, J. Joyce 413. Computational reconstruction of the protein secretion pathway in CHO cells. J.M. Gutierrez Bugarin, A. Feizi, N.E. Lewis 414. Examination of multivariate model generation using UV-vis spectral data for mAb titer. J. Miller, J.L. Coffman, P. Shamlou 415. Engineering the ligand affinity and specificity of the human adenosine A 2A receptor. J. Yoo, P.S. Daugherty, M.A. O'Malley 416. Computational investigation of mutational impact on terpene synthases. L. Li, C. Pirie 417. Use of Fc gamma receptors as chromatographic ligands to enrich high affinity subclasses and glycoforms from human plasma IgG. A. Boesch, T. Chu, H. Kappel, A. Mahan, G. Alter, M. Ackerman WEDNESDAY MORNING Westin San Diego Crystal II Upstream Processes Advances in Systems Biology Section A M. R. Antoniewicz, M. A. Blenner, V. Roy, Organizers N. Jacob, G. Sriram, Organizers, Presiding 8:30 418. Large scale dynamic models of metabolism as a tool for analysis and design of metabolic engineering and synthetic biology strategies. G. Fengos, L. Miskovic, V. Hatzimanikatis 8:50 419. Characterizing strain variation in engineered E. coli using a multi-omics based workflow. E.C. Brunk, K. George, J.D. Keasling, B. Palsson, T. Lee 9:10 420. Hierarchy of decisions that impact the accuracy of tissue-specific metabolic models. S. Opdam, N.E. Lewis 9:30 421. Technical evaluation of RNA-Seq and microarray approaches in comparative transcriptomics analysis of CHO cells. C. Chen, H. Le, C. Goudar
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Page 3 and 4: 9:10 19. Imaging the oxidation stat
Page 5 and 6: 4:00 39. Case study on the producti
Page 7 and 8: 3:40 61. Genome-scale engineering i
Page 9 and 10: 11:10 80. Cell death during product
Page 11 and 12: 10:10 100. Comprehensive bioconvers
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Page 15 and 16: 4:40 142. Evolving an intrinsically
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Page 19 and 20: 9:10 177. Rethinking affibody: Evol
Page 21 and 22: 8:30 196. Exploring enhancement of
Page 23 and 24: 4:00 217. Optimization of mAb charg
Page 25 and 26: 3:40 238. Application biophysical t
Page 27 and 28: 267. Gamma-aminobutyric acid produc
Page 29 and 30: 302. Inference of cohort-specific H
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Page 33: 373. Developmental approaches for o
Page 37 and 38: Section C Westin San Diego Diamond
Page 39 and 40: 11:05 455. Use of quality by design
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Page 47 and 48: 10:10 Panel Discussion. Section F W
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