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DESCRIPTIONS OF MEDICAL FUNGI

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38<br />

Descriptions of Medical Fungi<br />

Synonymy: Candida brumptii (Guerra) Langeron & Guerra.<br />

Although most isolates of Candida catenulata originate from human sources, cases of<br />

candidaemia are uncommon.<br />

RG-1 organism.<br />

Candida catenulata Diddens & Lodder<br />

Culture: Colonies (SDA) white to cream-coloured smooth, soft and wrinkled, yeastlike.<br />

Microscopy: Ovoid to cylindrical budding blastoconidia, 1.5-4.5 x 4-12 µm.<br />

India Ink Preparation: Negative - no capsules present.<br />

Dalmau Plate Culture: pseudohyphae consisting of chains of ovoid or cylindroid cells,<br />

and sometimes small verticils of ovoid blastoconidia.<br />

Physiological Tests: + Positive, - Negative, v Variable, w Weak, s Slow<br />

Germ Tube - L-Sorbose - L-Arabinose - D-Glucitol v<br />

Fermentation Sucrose - D-Arabinose - α-M-D-glucoside -<br />

Glucose v Maltose v D-Ribose v D-Gluconate v<br />

Galactose -,s Cellobiose - L-Rhamnose - DL-Lactate -<br />

Sucrose - Trehalose v D-Glucosamine v myo-Inositol -<br />

Maltose -,s Lactose - N-A-D-glucosamine + 2-K-D-gluconate v<br />

Lactose - Melibiose - Glycerol + D-Glucuronate -<br />

Trehalose - Raffinose - Erythritol - Nitrate -<br />

Assimilation Melezitose - Ribitol v Urease -<br />

Glucose + Soluble Starch v Galactitol - 0.1% Cycloheximide +,s<br />

Galactose + D-Xylose v D-Mannitol + Growth at 37 O C v<br />

Key Features: Separation from most physiologically similar species can be<br />

accomplished based on positive growth responses on D-mannitol, D-glucitol and<br />

resistance to 0.1% cycloheximide, combined with negative responses for sorbose and<br />

erythritol utilisation or growth in vitamin-free medium.<br />

Antifungal Susceptibility: C. catenulata (Australian National data); MIC µg/mL.<br />

No 64<br />

AmB 3 2 1<br />

FLU 3 1 1 1<br />

VORI 3 1 1 1<br />

POSA 3 2 1<br />

ITRA 3 1 1 1<br />

ANID 3 1 2<br />

MICA 3 1 2<br />

CAS 3 1 2<br />

5FC 3 3

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