Mid Rivers Newsmagazine 4-5-17

26 I MATURE FOCUS I
April 5, 2017
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Urban air pollution linked to increased risk of dementia/Alzheimer’s disease for older women.
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News and notes
Polluting the brain
New research has linked living in
air-polluted urban areas with a significantly
increased risk of dementia and
Alzheimer’s disease, at least for women.
The study, led by researchers from the
University of Southern California, was
based on data from thousands of women
between the ages of 65 and 79 living
throughout the U.S. who participated in
the Women’s Health Initiative Memory
Study.
Tiny, inhalable air pollution particles
known as PM2.5, which mainly come
from power plants and automobiles, are
the source of the long-term damage. The
research team found that older women
living in places where PM2.5 levels
exceed the U.S. Environmental Protection
Agency’s standard are 81 percent
more at risk for global cognitive decline,
and 92 percent more likely to develop
dementia, including Alzheimer’s. In the
general population, these findings indicate
that air pollution could be responsible
for about 21 percent of dementia
cases in women. The adverse effects of
pollution were stronger in women who
carry the APOE4 gene, which increases
the risk for Alzheimer’s.
“Microscopic particles generated by
fossil fuels get into our body directly
through the nose into the brain,” said
Professor Caleb Finch of the USC Leonard
Davis School of Gerontology, who
co-authored the study. “Cells in the brain
treat these particles as invaders and react
with inflammatory responses which, over
the course of time, appear to exacerbate
and promote Alzheimer’s disease.”
Concurrent to their analysis of women
participating in the memory study, the
USC scientists also conducted research in
female mice. Over a period of 15 weeks,
they chronically exposed mice that carried
the APOE4 gene to nano-sized air
pollution. They found that, compared to
See MATURE FOCUS, page 28
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