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Figure 4.18 1 H <strong>and</strong> 13 C NMR spectra of 4.44 recorded in CDCl3 at 600 MHz <strong>and</strong> 150 MHz<br />

respectively. .......................................................................................................................... 247<br />

Figure 5.1 Hydrolysis of a peptide by a cysteine protease. .................................................. 249<br />

Figure 5.2 Peptide-aldehyde inhibitors of cysteine proteases. .............................................. 251<br />

Figure 5.3 Covalent binding mechanism between a peptide-aldehyde natural product <strong>and</strong> a<br />

cysteine protease. .................................................................................................................. 252<br />

Figure 5.4 Novel peptide-aldehyde lichostatinal (5.4). ......................................................... 253<br />

Figure 5.5 1 H <strong>and</strong> 13 C NMR spectra of 5.12 recorded in (CD3)2SO at 400 MHz <strong>and</strong> 100 MHz<br />

respectively. .......................................................................................................................... 266<br />

Figure 5.6 1 H <strong>and</strong> 13 C NMR spectra of 5.13 recorded in D2O at 400 MHz <strong>and</strong> 100 MHz<br />

respectively. .......................................................................................................................... 268<br />

Figure 5.7 1 H <strong>and</strong> 13 C NMR spectra of 5.15 recorded in (CD3)2SO at 600 MHz <strong>and</strong> CD2Cl2 at<br />

150 MHz respectively. .......................................................................................................... 270<br />

Figure 5.8 1 H <strong>and</strong> 13 C NMR spectra of 5.16 recorded in (CD3)2SO at 600 MHz <strong>and</strong> 150 MHz<br />

respectively. .......................................................................................................................... 272<br />

Figure 5.9 1 H <strong>and</strong> 13 C NMR spectra of 5.18 recorded in (CD3)2SO at 600 MHz <strong>and</strong> 150 MHz<br />

respectively. .......................................................................................................................... 275<br />

Figure 5.10 1 H <strong>and</strong> 13 C NMR spectra of 5.20 recorded in (CD3)2SO at 600 MHz <strong>and</strong> 150<br />

MHz respectively. ................................................................................................................. 278<br />

Figure 5.11 1 H <strong>and</strong> 13 C NMR spectra of 5.24 recorded in (CD3)2SO at 600 MHz <strong>and</strong> 150<br />

MHz respectively. ................................................................................................................. 280<br />

Figure 5.12 1 H <strong>and</strong> 13 C NMR spectra of 5.29 recorded in CD2Cl2 at 600 MHz <strong>and</strong> 100 MHz<br />

respectively. .......................................................................................................................... 282<br />

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