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Chapter 2: Synthesis and Biological Evaluation of SHIP1 Activators
2.1 Inhibition of PI3K Signaling by Activation of SHIP1
Figure 2.1 The PI3K pathway.
The Phosphoinositide 3-kinase (PI3K) signal transduction pathway (Figure 2.1)
regulates many cellular processes such as cell proliferation, activation, and growth. 42,43,44,45
Specific binding between extracellular ligands and receptors on the cell surface activate the
PI3K pathway, which leads to phosphorylation of phosphatidylinositol-4,5-bisphosphate (PI-
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