RVB Translational Medicine Book

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Naam/titel subtitel bodytekst 88 Translational Medicine
“We have one research line from the bed of the patient to the molecules in the lab. It is not a one-way street: it is dynamic and it goes back and forth.” Jeroen Pasterkamp Professor of Translational Neuroscience, Director of MIND Facility, and Chair of Strategic Research Program Brain The lab of Jeroen Pasterkamp is translational in several different ways. He explains, “First of all, we try to understand how the brain normally develops and works, from a basic research perspective. We use the normal situation as a standard, and then compare it to the injured or diseased situation. Another strategy is to use genetic information, brain resection material, or cultured human neurons from patients as a starting point. We can then use this to identify the cellular and molecular mechanisms that are affected in different diseases.” “Translational Medicine in the field of neurosciences is different from other fields, because the nervous system is a complex organ and we do not know much about it. We are trying to fix the patient’s problem, but at the same time we are trying to understand how the brain works,” Jeroen explains. The enthusiastic professor is proud of having achieved an efficient method to work with the clinic for studying both motor neuron disease and epilepsy. “For example, we have one research line in studying ALS, or amyotrophic lateral sclerosis, that extends from the bed of the patient to the molecules we study in the lab. It is not a one-way street: it is dynamic, it goes back and forth. And, we collaborate with the entire world.” UMC Utrecht 89
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“The solution to major medical pr
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Education and Research on Translati
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Page 39 and 40: “There is a bright idea or health
Page 41 and 42: “In my research, I try to keep in
Page 43 and 44: UMC Utrecht 41
Page 45 and 46: “At the UMC Utrecht, people talk
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Page 51 and 52: UMC Utrecht Eureka Summer Course on
Page 57 and 58: “I call myself a translational sc
Page 61 and 62: “From the beginning to the end, i
Page 63 and 64: “In the future, Translational Med
Page 67 and 68: “Translational Medicine is not th
Page 69 and 70: “My role model is Hans Clevers. H
Page 73 and 74: “Academia and industry need to wo
Page 75 and 76: “My role model is Leonard Cohen:
Page 79 and 80: “My involvement with Apollo Socie
Page 81 and 82: “My role model is embodied in sev
Page 85 and 86: “The field of medicine is changin
Page 87 and 88: “I feel that frequent inspiration
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Page 93 and 94: “What I am proud of is that, toge
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