Fertility Road Issue 03

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Nicosia IVF located in North Cyprus combines beautiful bays, enchanting sights & sunny climate all year round, making it an ideal get-away for your fertility treatments, including: IVF – ICSI treatment - IVF is a procedure being performed since 1978 in the world. It is an important solution for couples who suffer from ovulation problems, sperm problems, uterine problems and also from unknown reasons. Egg Donation Program - Egg donation is widely popular because success rates are greater compared to regular IVF treatments. Our clinic does not do egg sharing and use all eggs of a woman for the same patient PGD Sex Selection - PGD (pre implantation genetic diagnosis) is an embryology technique that actually can detect chromosomal problems, single – gene diseases and save a child from serious illnesses... Advantages of having an IVF treatment in Northern Cyprus • No waiting lines • Availibility of maximum 3 embryo transfer at the blastocyst stage • Availability of Egg donation, sperm donation, embryo donation, and PGD procedures • Modern Technology, high success rates • Get-away environment will relax the couple during this treatment • English Speaking Personnel info@nicosiaivf.co.uk tel: 020 8133 31 21 www.nicosiaivf.co.uk SUBSCRIBE TO FERTILITY ROAD TODAY AND SAVE! Fertility Road is Europe’s number one fertility magazine, aimed at guiding women and men on the path to parenthood. Its lifestyle-feel is a breath of fresh air in an industry sometimes obsessed with science, and in each issue we offer you the stories behind top celebrity names, plus advice, information and stimulating features from some of the UK’s most accomplished fertility writers, tackling issues ranging from health, diet, finance and travel, through to law, exercise and same-sex parenting. We showcase the latest developments and present your heartfelt and often optimistic stories. SUBSCRIBE NOW! You can subscribe by emailing subscriptions@fertilityroad.com or by following the ‘Subscribe Now’ link online at www.fertilityroad.com. Alternatively cut out this form and send it in the post to the address listed, attaching a cheque or postal order for the relevant amount. Yes, I would like to subscribe to Fertility Road magazine 3 issues for £10.35 6 issues for £18.30 p&p is free Your Details: Mobile No Email EUROPE'S NO.1 FERTILITY MAGAZINE YOUR PATH TO PARENTHOOD ZITA WEST EXCLUSIVE READER Q&A Think Twice Celine Dion's IVF twin elation TONI WESCHLER FERTILITY ON THE WEB CHINESE MEDICINE ISSUE 03 | NOVEMBER / DECEMBER 2010 £3.95/€4.95 WWW.FERTILITYROAD.COM FERTILITY ON ICE Social egg freezing - exclusive report IT'S MY LIFE Pregnancy, prying eyes and snooping glances SUBSCRIBE TODAY AND SAVE ISSUE 03 WWW.FERTILITYROAD.COM £££’s Name Address Signature Date Post code To receive great offers, news, products and service information from Fertility Road, via email and SMS please tick this box Send subscriptions to: Fertility Road magazine, Suite 318, Building 50, Argyll Road, Royal Arsenal, Woolwich, London, SE18 6PP. 58 fertility road | november - december
SCIENCE | sperm dna fragmentation SPERM DNA FRAGMENTATION By Dr Preben Christensen, from SPZ Lab in Denmark © Sebastian Kaulitzki / shutterstock.com Recently, there has been increased emphasis on the evaluation of sperm quality. Much of this has been due a growing realisation that a sperm or semen test is actually of limited value. Sperm, in essence, act as little more than vehicles by which DNA is carried from the male to the female egg. Only very few make it to their goal, and along the way a potentially damaging process is undertaken, where the protein blocks designed to protect the sperm can very often fail, leaving DNA susceptible to damage and at risk of becoming fragmented. There have been significant recent studies into DNA fragmentation, and I have outlined below the latest findings into an area of fertility previous not given the attention it perhaps deserves. Historically, infertility has been a problem that was believed to originate solely from the woman. About 300 years ago, people were pretty sure that “what father does is always right!” The Dutchman Nicolas Hartsoecker was one of the first to look at a sperm sample under the microscope. He drew a ‘Homunculus’, a small child in the head of the sperm cell, and the belief was that anything produced by the man would have to be perfect. This example tells us that one of our problems when trying to understand new research is our entire perception of the problem! Thus, approximately 75% of all women believe that it can only be the woman that is the problem when a fertilised egg does not implant in the uterus. And that is despite the fact that nowadays most men are aware of the fact that sperm quality can be a problem. Indeed, in approximately every fourth childless couple, the reason for the involuntary childlessness is DNA fragmentation in the sperm cells. The vast majority of these men have normal sperm quality, the problem being that you cannot see when the genome (the DNA) is not packed properly in the sperm cell. The concentration of sperm cells can be fine, they are swimming properly and can easily fertilise the egg. However, the fertilised egg is still doomed to perish. The reason for this is that the genome from the sperm cell has been damaged (fragmented) during the long journey to the egg. The egg might be able to carry out small repairs of the sperm cell’s DNA, but major damage is fatal for the further development of the egg. In other words, the woman’s eggs might be perfectly fine – but with a fragmented genome in the sperm cells, the fertilisation will not result in a viable foetus. The most extensive study carried out so far regarding the significance of DNA fragmentation in sperm cells was conducted by Mona Bungum at Malmø University Hospital and was published in 2007 in the journal Human Reproduction. The study was based on 998 treatment cycles, where the couples received either IUI, IVF or ICSI Historically, infertility has been a problem that was believed to originate solely from the woman. About 300 years ago, people were pretty sure that “what father does is always right!” treatment. Mona showed that the DNA fragmentation index (DFI) was above 25 for approximately 27% of the infertile couples in her study. At this level itz is basically impossible to get the wished-for child through IUI treatment. For approximately 5% of the couples, the DFI was above 50. At this level, IVF treatment will not have the desired result either. In other words, this is a very frequent problem. It’s also something of a hidden problem, because when the fertilised egg starts splitting, the first breaks take place without any influence from the genome of the sperm cell. Not until there are eight cells does the egg start drawing on information from the sperm cell. » www.fertilityroad.com 59
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EUROPE'S NO.1 FERTILITY MAGAZINE IS
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FERTILITY ROAD CONTENTS In this iss
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ISSUE 03 | NOVEMBER / DECEMBER 2010
Page 7 and 8: FERTILITY ROAD NEWS The latest deve
Page 14 and 15: FERTILITY ROAD CELEB NEWS Fertility
Page 16 and 17: FERTILITY ROAD FERTILITY FINDS The
Page 18 and 19: FEATURE | it’s my life WORDS | KE
Page 20 and 21: A Caring Approach to Egg Donation P
Page 22: FEATURE | it’s my life SO WHAT CA
Page 25: She is a fertility expert who has t
Page 28 and 29: INTERVIEW | Toni Weschler or ovulat
Page 30 and 31: FEATURE | fertility on ice FERTILIT
Page 32 and 33: PensThatCommunicate_FertilyRoad_Adv
Page 34 and 35: FEATURE | same-sex parenting
Page 36 and 37: treatment option? Want to be a dad?
Page 38 and 39: FEATURE | same-sex parenting The ap
Page 40 and 41: EGG DONOR PROGRAM no waiting lists
Page 42 and 43: FEATURE | worldwide web of fertilit
Page 44 and 45: FEATURE | worldwide web of fertilit
Page 46 and 47: TM Pregnancy Companion A doctor’s
Page 48 and 49: FERTILITY ROAD GUIDES/LAW Helping y
Page 50 and 51: At MFP we understand all that it is
Page 52 and 53: FERTILITY ROAD | Rosjurconsulting I
Page 54 and 55: Q&A | zita west EXPERT WITNESS WITH
Page 56 and 57: FERTILITY ROAD GUIDES/ACUPUNCTURE H
Page 60 and 61: SCIENCE | sperm dna fragmentation T
Page 62 and 63: READER STORY | letter from the hear
Page 64 and 65: Weywelcomeyyouytoythey2 nd yInterna
Page 66 and 67: FERTILITY ROAD | not forgotten THE
Page 68: COST - LOW / SUCCESS - HIGH / WAITI
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