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Section 2: The musculoskeletal system and exercise<br />

KEY POINTS<br />

Epimysium: the tough membrane that surrounds the whole muscle belly and holds the smaller fasciculi<br />

units together.<br />

Perimysium: the membrane which surrounds the bundles of muscle fibres (the fasciculi).<br />

Endomysium: the membrane that surrounds the <strong>in</strong>dividual muscle fibres, which conta<strong>in</strong> the myofibrils.<br />

Tendon: tough, <strong>in</strong>elastic fibres which wrap around the end of the muscle and attach it to the outer layer<br />

of the bone.<br />

Myofibril: the smallest unit, or fibril, with<strong>in</strong> the <strong>in</strong>dividual muscle fibres.<br />

Myofilaments: the contractile prote<strong>in</strong>s myos<strong>in</strong> and act<strong>in</strong> arranged with<strong>in</strong> compartments <strong>in</strong> the myofibril<br />

called sarcomeres.<br />

Force generation and the slid<strong>in</strong>g filament theory<br />

Force generation beg<strong>in</strong>s with the two contractile prote<strong>in</strong>s myos<strong>in</strong> and act<strong>in</strong> (often referred to as thick and<br />

th<strong>in</strong> filaments respectively). As previously stated, these are arranged <strong>in</strong> a series of compartments called<br />

sarcomeres that run the length of the myofibril.<br />

Act<strong>in</strong> filament<br />

SARCOMERE IS RELAXED<br />

SARCOMERE IS CONTRACTED<br />

Myos<strong>in</strong> filament<br />

Muscle fibre<br />

Myofibril<br />

Figure 2.2 The slid<strong>in</strong>g filament theory<br />

The act<strong>in</strong> (th<strong>in</strong> filament) is<br />

anchored to the ends of the<br />

sarcomere and the myos<strong>in</strong><br />

(thick filament) sits with<strong>in</strong><br />

the middle of the sarcomere,<br />

pull<strong>in</strong>g the act<strong>in</strong> from either<br />

end towards the middle to<br />

generate tension. Spirall<strong>in</strong>g<br />

from the myos<strong>in</strong> filament is a<br />

series of ‘hook like’ projections<br />

referred to as myos<strong>in</strong><br />

heads. Dur<strong>in</strong>g muscular<br />

contraction, these heads<br />

attach themselves to the act<strong>in</strong><br />

filaments and rotate, pull<strong>in</strong>g<br />

on these filaments. The result<br />

of this is that the th<strong>in</strong>ner<br />

act<strong>in</strong> filaments are drawn<br />

<strong>in</strong>wards, dragg<strong>in</strong>g the ends of<br />

the sarcomeres together; this<br />

is referred to as the slid<strong>in</strong>g<br />

filament mechanism. The<br />

characteristic contraction of<br />

muscles is caused by multiple<br />

sarcomeres shorten<strong>in</strong>g<br />

simultaneously.<br />

Anatomy and physiology for exercise and health<br />

Copyright © 2017 <strong>Active</strong> <strong>IQ</strong> Ltd. Not for resale | 15

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