No. 104 - Miljøstyrelsen
No. 104 - Miljøstyrelsen
No. 104 - Miljøstyrelsen
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LOAEL corresponds to the Danish occupational threshold limit value<br />
mentioned above. Corrected for long-term exposure 8<br />
(from working<br />
environment to normal population) the LOAEL becomes 0.009 mg Hg/m 3<br />
(9<br />
µg Hg/m 3<br />
). These values are based on adverse effects such as tremor and<br />
memory loss.<br />
Agency for Toxic Substances Disease Registry (ATSDR) set in 1999 a<br />
minimum risk level (MRL) of 0.0002 mg Hg/m 3 (0,2 µg Hg/m 3 ). In addition,<br />
TSDR has recommended concentration limits after cleaning and spillage<br />
indoors (ATSDR, 1999).<br />
In 2005 EPA in California established a long-term Reference Exposure Level<br />
(REL) of 0.00003 mg Hg/m 3 (0.03 µg Hg/m 3 ) on the basis of a LOAEL of<br />
0.025 mg Hg/m 3 (25 µg Hg/m 3 ) in the working environment (OEHHA,<br />
2008). An adjustment to normal population exposure gave a LOAEL of<br />
0.009 mg Hg/m 3 (9 µg Hg/m 3 ) (corresponds to USEPA above). This was<br />
converted to REL by using larger (un)certainty factors than those used by<br />
USEPA:<br />
� An (un)certainty factor of 10, due to the fact that it is not a NOAEL,<br />
� An (un)certainty factor of 30 for particular sensitivity of children,<br />
variation between individuals and for sensitivity of nervous system<br />
under development.<br />
CalEPA has furthermore set a limit value of 0.0018 mg/m 3<br />
exposure of one hour (Groth, 2008).<br />
(1.8 µg/m 3<br />
) for an<br />
A new Canadian assessment assumes a LOAEL value of 0.006 mg Hg/m 3 (6<br />
µg Hg/m 3 ). With an (un)certainty factor of 100 for uncertainty and modifying<br />
factors the result is a REL of 0.00006 mg Hg/m 3 (0,06 µg Hg/m 3 )<br />
(Richardson et al., 2009).<br />
A summary of information about limit values long-term mercury exposure is<br />
given in Table 4-2.<br />
8<br />
I.e. multiplied by a factor 5/7 to take into account all seven days of the week and not<br />
only five workdays, and a factor 10/20 to take into account a respiratory volume of 10<br />
for a workday and 20 m 3<br />
for 24 hours.<br />
m 3<br />
41