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genetic association study. BMC Cancer 2008; 8: 326 18 Li A, Varney ML, Valasek J, Godfrey M, Dave BJ, Singh RK. Autocrine role of interleukin-8 in induction of endothelial cell proliferation, survival, migration and MMP-2 production and angiogenesis. Angiogenesis 2005; 8: 63-71 19 Landi S, Moreno V, Gioia-Patricola L, Guino E, Navarro M, de Oca J, Capella G, Canzian F. Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor alpha, NFKB1, and peroxisome proliferator-activated receptor gamma with colorectal cancer. Cancer Res 2003; 63: 3560-3566 20 McCarron SL, Edwards S, Evans PR, Gibbs R, Dearnaley DP, Dowe A, Southgate C, Easton DF, Eeles RA, Howell WM. Influence of cytokine gene polymorphisms on the development of prostate cancer. Cancer Res 2002; 62: 3369-3372 21 van der Kuyl AC, Polstra AM, Weverling GJ, Zorgdrager F, van den Burg R, Cornelissen M. An IL-8 gene promoter polymorphism is associated with the risk of the development of AIDS-related Kaposi’s sarcoma: a case-control study. AIDS 2004; 18: 1206-1208 22 Wei YS, Lan Y, Tang RG, Xu QQ, Huang Y, Nong HB, Huang WT. Single nucleotide polymorphism and haplotype WJG|www.wjgnet.com Mustapha MA et al . Risk modification by interleukin-8 SNP association of the interleukin-8 gene with nasopharyngeal carcinoma. Clin Immunol 2007; 125: 309-317 23 Hussain SP, Hofseth LJ, Harris CC. Radical causes of cancer. Nat Rev Cancer 2003; 3: 276-285 24 Marnett LJ. Oxyradicals and DNA damage. Carcinogenesis 2000; 21: 361-370 25 Meira LB, Bugni JM, Green SL, Lee CW, Pang B, Borenshtein D, Rickman BH, Rogers AB, Moroski-Erkul CA, McFaline JL, Schauer DB, Dedon PC, Fox JG, Samson LD. DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. J Clin Invest 2008; 118: 2516-2525 26 Kraus S, Arber N. Inflammation and colorectal cancer. Curr Opin Pharmacol 2009; 9: 405-410 27 Roessner A, Kuester D, Malfertheiner P, Schneider-Stock R. Oxidative stress in ulcerative colitis-associated carcinogenesis. Pathol Res Pract 2008; 204: 511-524 28 Okada F, Shionoya H, Kobayashi M, Kobayashi T, Tazawa H, Onuma K, Iuchi Y, Matsubara N, Ijichi T, Dugas B, Hosokawa M. Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase. Br J Cancer 2006; 94: 854-862 S- Editor Cheng JX L- Editor Kerr C E- Editor Xiong L 2673 June 7, 2012|Volume 18|Issue 21|
Online Submissions: http://www.wjgnet.com/1007-9327office wjg@wjgnet.com doi:10.3748/wjg.v18.i21.2674 World J Gastroenterol 2012 June 7; 18(21): 2674-2681 ISSN 1007-9327 (print) ISSN 2219-2840 (online) © 2012 Baishideng. All rights reserved. Eradication of Helicobacter pylori increases childhood growth and serum acylated ghrelin levels Yao-Jong Yang, Bor-Shyang Sheu, Hsiao-Bai Yang, Cheng-Chan Lu, Ching-Chun Chuang Yao-Jong Yang, Departments of Pediatrics and Institute of Clinical Medicine, Medical College, National Cheng Kung University, Tainan 70428, Taiwan, China Bor-Shyang Sheu, Departments of Internal Medicine and Institute of Clinical Medicine, Medical College, National Cheng Kung University, Tainan 70428, Taiwan, China Hsiao-Bai Yang, Ton-Yen General Hospital, Hsinchu County 70428 Taiwan, China Hsiao-Bai Yang, Cheng-Chan Lu, Department of Pathology, Medical College, National Cheng Kung University, Tainan 70428, Taiwan, China Ching-Chun Chuang, Institute of Clinical Medicine, Medical College, National Cheng Kung University, Tainan 70428, Taiwan, China Author contributions: Yang YJ contributed to the study design, study performance, and wrote the first draft of the manuscript; Yang HB and Lu CC contributed to the study design, technique consultation and paper revision; Chuang CC performed the research and analyzed the data; Sheu BS organized the whole study design, team discussion and final revision of this paper. Supported by National Cheng Kung University Hospital, Tainan, China, No. NCKUH96030; and DOH99TDC111003 from Department of Health, Taiwan, China, No. DOH99TDC111003 Correspondence to: Bor-Shyang Sheu, �ro�essor, �ro�essor, Depart- ment of Internal Medicine, National Cheng Kung University Hospital, No. 138 Sheng Li Road, Tainan 70428, Taiwan, China. sheubs@mail.ncku.edu.tw Telephone: +88662353535 Fax: +88662370941 Received: August 9, 2011 Revised: December 8, 2011 Accepted: April 28, 2012 �ublished online: June 7, 2012 Abstract AIM: To determine whether Helicobacter pylori (H. pylori)in�ected children have reduced body weight (BW) and height (BH) growth, and i� H. pylori eradication may restore growth while improving serum acylated ghrelin. METHODS: This longitudinal cohort study with oneyear �ollow-up enrolled 1222 children aged 4 to 12 years old into an observation cohort (18 with and 318 WJG|www.wjgnet.com BRIEF ARTICLE without H. pylori ) and intervention cohort (75 with and 811 without). The 7-d triple therapy was used �or eradication in the intervention cohort. The net increases o� BW and BH as well serum acylated ghrelin a�ter oneyear �ollow-up were compared between success�ul eradicated H. pylori -in�ected children and controls. RESULTS: In the observation cohort, the H. pylori - in�ected children had lower z score o� BW (-1.11 ± 0.47 vs 0.35 ± 0.69, � = 0.01) and body mass index (BMI) (0.06 ± 0.45 vs 0.44 ± 0.73, � = 0.02) at enrollment and lower net BW gain a�ter one-year �ollow-up (3.3 ± 2.1 kg vs 4.5 ± 2.4 kg, � = 0.04) than the non-in�ected controls. In the intervention cohort, the H. pylori - in�ected children had lower z score o� BMI (0.25 ± 1.09 vs 0.68 ± 0.87, � = 0.009) and serum acylated ghrelin levels (41.8 ± 35.6 pg/mL vs 83.6 ± 24.2 pg/mL, � < 0.001) than the non-in�ected controls. In addition to restoring decreased serum ghrelin levels (87.7 ± 38.0 pg/mL vs 44.2 ± 39.0 pg/mL, � < 0.001), the H. pylori - in�ected children with success�ul eradication had higher net gains (� < 0.05) and increase o� z scores (� < 0.05) o� both BW and BH as compared with non-in�ected controls a�ter one-year �ollow-up. CONCLUSION: H. pylori -in�ected children are associated with low serum acylated ghrelin and growth retardation. Success�ul eradication o� H. pylori restores ghrelin levels and increases growth in children. © 2012 Baishideng. All rights reserved. Key words: Child; Clinical trial; Ghrelin; Growth retardation; Helicobacter pylori Peer reviewer: Francesco Franceschi, MD, PhD, Assistant Professor, Internal Medicine, Catholic University of Rome, Gemelli Hospital, 00168 Rome, Italy Yang YJ, Sheu BS, Yang HB, Lu CC, Chuang CC. Eradication of Helicobacter pylori increases childhood growth and serum acylat- 2674 June 7, 2012|Volume 18|Issue 21|
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World Journal of Gastroenterology W
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Phillip S Oates, Perth Ross C Smith
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Deepak N Amarapurkar, Mumbai Abhiji
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Trine Olsen, Tromsø Eyvind J Pauls
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Conor P Delaney, Cleveland Sharon D
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S Contents EDITORIAL FIELD OF VISIO
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Contents ACKNOWLEDGMENTS APPENDIX A
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Cereda S et al . Adjuvant treatment
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DM, Sterling RK, Shiffman M, Topaz
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Selinger CP et al . Pregnancy relat
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Page 46 and 47: A Macroscopir damage scores (AU) 7.
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Page 57 and 58: A Fold changes over untreated cells
Page 59 and 60: A Migration Invasion B Migration In
Page 61 and 62: A miR-95 B Li WG et al �� Glarg
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Page 67 and 68: A HT29 cells 100 C SW116 cells 40 P
Page 69 and 70: A B Ecadherin Vimentin GAPDH Zhou H
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Page 101 and 102: A Serum acylated ghrelin (pg/mL) B
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Nishizawa T et al . Dual therapy fo
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Instructions to authors ISSN and EI
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Instructions to authors AIM (no mor
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Instructions to authors Guidelines
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