26 - World Journal of Gastroenterology

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1st ed. Peking: Peking University Medical Press, 2004: 110 23 Tessaro I, Mangone C, Parkar I, Pawar V. Knowledge, barriers, and predictors of colorectal cancer screening in an Appalachian church population. Prev Chronic Dis 2006; 3: A123 24 Nguyen BH, McPhee SJ, Stewart SL, Doan HT. Colorectal cancer screening in Vietnamese Americans. J Cancer Educ 2008; 23: 37-45 25 Jo AM, Maxwell AE, Wong WK, Bastani R. Colorectal cancer screening among underserved Korean Americans in Los Angeles County. J Immigr Minor Health 2008; 10: 119-126 26 Berkowitz Z, Hawkins NA, Peipins LA, White MC, Nadel MR. Beliefs, risk perceptions, and gaps in knowledge as barriers to colorectal cancer screening in older adults. J Am Geriatr Soc 2008; 56: 307-314 27 Hou SI. Factors associated with intentions for colorectal cancer screenings in a Chinese sample. Psychological reports 2005; 96: 159-162 28 Deng SX, Cai QC, An W, Gao J, Hong SY, Zhu W, Li ZS. [Factors influencing patient compliance in colorectal cancer screening: qualitative research synthesis]. Zhonghua Yixue WJG|www.wjgnet.com Deng SX et al . Colorectal cancer screening behavior and willingness Zazhi 2010; 90: 2679-2683 29 Ward E, Halpern M, Schrag N, Cokkinides V, DeSantis C, Bandi P, Siegel R, Stewart A, Jemal A. Association of insurance with cancer care utilization and outcomes. CA Cancer J Clin 2008; 58: 9-31 30 Roetzheim RG, Pal N, Tennant C, Voti L, Ayanian JZ, Schwabe A, Krischer JP. Effects of health insurance and race on early detection of cancer. Journal of the National Cancer Institute 1999; 91: 1409-1415 31 Delgado-Plasencia L, López-Tomassetti-Fernández E, Hernández-Morales A, Torres-Monzón E, González-Hermoso F. Willingness to undergo colorectal cancer screening in first-degree relatives of hospitalized patients with colorectal cancer. J Med Screen 2009; 16: 33-38 32 Liang SY, Phillips KA, Nagamine M, Ladabaum U, Haas JS. Rates and predictors of colorectal cancer screening. Prev Chronic Dis 2006; 3: A117 33 Lafata JE, Williams LK, Ben-Menachem T, Moon C, Divine G. Colorectal carcinoma screening procedure use among primary care patients. Cancer 2005; 104: 1356-1361 S- Editor Tian L L- Editor Ma JY E- Editor Ma WH 3139 July 14, 2011|Volume 17|Issue 26|
Online Submissions: http://www.wjgnet.com/1007-9327office wjg@wjgnet.com doi:10.3748/wjg.v17.i26.3140 High incidence of biliary complications in rat liver transplantation: Can we avoid it? BRIEF ARTICLE Guo-Lin Li, Hao-Ming Lin, Tian-Zhu Long, Li-Hong Lv, Jian-Dong Yu, Yong-Heng Huang, Jun Min, Yun-Le Wan Guo-Lin Li, Li-Hong Lv, Jian-Dong Yu, Yong-Heng Huang, Jun Min, Hao-Ming Lin, Yun-Le Wan, Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Haizhu District, Guangzhou 510260, Guangdong Province, China Tian-Zhu Long, Department of Breast Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou 510260, Guangdong Province, China Author contributions: Li GL and Long TZ performed the majority of experiments and wrote the manuscript; Lv LH, Yu JD and Huang YH collected all animal samples and edited the manuscript; Min J guided the experiment and provided financial support for this work; Wan YL designed the study and also offered financial support; Lin HM guided the experiment and edited the manuscript. Supported by the National Natural Science Foundation of China, No. 30671987 Correspondence to: Yun-Le Wan, PhD, Professor, Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yatsen University, No. 33 Yingfeng Road, Haizhu District, Guangzhou 510260, Guangdong Province, China. wanyldr@163.com Telephone: +86-20-34071163 Fax: +86-20-34071080 Received: January 29, 2011 Revised: March 24, 2011 Accepted: March 31, 2011 Published online: July 14, 2011 Abstract AIM: To investigate how to reduce the incidence of biliary complications in rat orthotopic liver transplantation. METHODS: A total of 165 male Wistar rats were randomly divided into three groups: Group A, orthotropic liver transplantation with modified “two-cuff” technique; Group B, bile duct was cut and reconstructed without transplantation; and Group C, only laparotomy was performed. Based on the approaches used for biliary reconstruction, Group A was divided into two sub-groups: A1 (n = 30), duct-duct reconstruction, and A2 (n = 30), duct-duodenum reconstruction. To study the influence of artery reconstruction on bile duct complication, Group B WJG|www.wjgnet.com 3140 World J Gastroenterol 2011 July 14; 17(26): 3140-3144 ISSN 1007-9327 (print) ISSN 2219-2840 (online) © 2011 Baishideng. All rights reserved. was divided into four sub-groups: B1 (n = 10), duct-duct reconstruction with hepatic artery ligation, B2 (n = 10), duct-duct reconstruction without hepatic artery ligation, B3 (n = 10), duct-duodenum reconstruction with hepatic artery ligation, and B4 (n = 10), duct-duodenum reconstruction without hepatic artery ligation. The samples were harvested 14 d after operation or at the time when significant biliary complication was found. RESULTS: In Group A, the anhepatic phase was 13.7 ± 1.06 min, and cold ischemia time was 50.5 ± 8.6 min. There was no significant difference between A1 and A2 in the operation duration. The time for biliary reconstruction was almost the same among all groups. The success rate for transplantation was 98.3% (59/60). Significant differences were found in the incidence of biliary complications in Groups A (41.7%), B (27.5%) and C (0%). A2 was more likely to have biliary complications than A1 (50% vs 33.3%). B3 had the highest incidence of biliary complications in Group B. CONCLUSION: Biliary complications are almost inevitable using the classical “two cuff” techniques, and duct-duodenum reconstruction is not an ideal option in rat orthotopic liver transplantation. © 2011 Baishideng. All rights reserved. Key words: Rat; Liver transplantation; Biliary complication; Animal model Peer reviewer: Salvatore Gruttadauria, MD, Assistant Professor, Abdominal Transplant Surgery, ISMETT, Via E. Tricomi, 190127 Palermo, Italy Li GL, Lin HM, Long TZ, Lv LH, Yu JD, Huang YH, Min J, Wan YL. High incidence of biliary complications in rat liver transplantation: Can we avoid it? World J Gastroenterol 2011; 17(26): 3140-3144 Available from: URL: http://www.wjgnet. com/1007-9327/full/v17/i26/3140.htm DOI: http://dx.doi. org/10.3748/wjg.v17.i26.3140 July 14, 2011|Volume 17|Issue 26|
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World Journal of Gastroenterology W
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Robert JL Fraser, Daw Park Jacob Ge
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Italy Donato F Altomare, Bari Piero
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Fernando Azpiroz, Barcelona Ramon B
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S Contents EDITORIAL REVIEW ORIGINA
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Contents APPENDIX FLYLEAF EDITORS F
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of HCC. Multimodal approaches with
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15S): A4577 63 Gruenwald V, Wilkens
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cause of liver disease in pediatric
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Table 1 Published studies on the as
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genesis through the presence of abn
Page 26 and 27: Manini R, Natale S, Vanni E, Villan
Page 28 and 29: Murray KF, Abrams SH, Rosenthal P,
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Page 34 and 35: The role of chemokines in CAC is fu
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Page 38 and 39: Online Submissions: http://www.wjgn
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Page 42 and 43: Table 1 Upregulation of heme oxygen
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Page 57 and 58: Table 1 Fundic somatostatin mRNA in
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Page 79 and 80: Li GL et al . Biliary complications
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